Primary Wilms tumor of the urinary bladder

Mayur Parkhi; Srinivasan Peyam; Nitin James Peters; Kushaljit Singh Sodhi; Amita Trehan; Amanjit Bal

doi:10.4322/acr.2021.390

Clinical Case Report

Primary Wilms tumor of the urinary bladder

Mayur Parkhi; Srinivasan Peyam; Nitin James Peters; Kushaljit Singh Sodhi; Amita Trehan; Amanjit Bal

http://dx.doi.org/10.4322/acr.2021.390 Autops Case Rep, vol.12, e2021390, 2022

PDF

Downloads: 1

Abstract

Wilms tumor (WT) can occur at various extrarenal sites; however, the urinary bladder as the primary site is occasional. A 4-year-old-female child presented with difficulty in micturition for the past month. The contrast-enhanced magnetic resonance imaging with magnetic resonance (MR) urography revealed a polypoidal, heterogeneous mass in the urinary bladder with no abnormality in the kidneys. Cystoscopy-guided biopsy was reported as an extrarenal Wilms tumor (ERWT) with triphasic components. Post-chemotherapy, a computed tomography scan revealed a residual tumor for which she underwent partial cystectomy. The diagnosis of ERWT was confirmed. She received adjuvant chemotherapy and remained well at the 9^th month post completion of chemotherapy. The primary bladder WT must be considered in the differential of a small blue round cell tumor at an extrarenal site in the pediatric age group. The diagnosis is especially challenging in small biopsy material, although it has immense significance in management and prognosis.

Keywords

Wilms Tumor, Urinary Bladder, Antineoplastic Agents, Cystectomy

References

1 Webber BL, Parham DM, Drake LG, Wilimas JA. Renal tumors in childhood. Pathol Annu. 1992;27(Pt 1):191-232. PMid:1310535.

2 Goldblum JR, Lamps LW, McKenney JK, Myers JL. Rosai and Ackerman’s Surgical Pathology. 11th ed. USA: Elsevier.

3 Zhang DY, Lin T, Wei GH, et al. A rare case of simultaneous occurrence of Wilms’ tumor in the left kidney and the bladder. Pediatr Surg Int. 2010;26(3):319-22. http://dx.doi.org/10.1007/s00383-009-2548-y. PMid:20063003.

4 Ismy J, Ismy J, Kamarlis R, Mustafa A. Rare case of primary bladder Wilm’s tumor in a 1-year-old boy. Urol Case Rep. 2019;25:100898. http://dx.doi.org/10.1016/j.eucr.2019.100898. PMid:31080741.

5 Sindhu II, Saeed H, Wali R, Mehreen A. Primary extra-renal Wilms’ tumor in urinary bladder: rare presentation of a common pediatric malignancy. J Coll Physicians Surg Pak. 2019;29(6):S31-3. http://dx.doi.org/10.29271/jcpsp.2019.06.S31. PMid:31142414.

6 Moyson F, Maurus-Desmarez R, Gompel C. Mediastinal Wilms’ tumor? Acta Chir Belg. 1961;2(Suppl. 2):118-28. PMid:14476767.

7 Armanda V, Culić S, Pogorelić Z, Kuljiš D, Budimir D, Kuzmić-Prusac I. Rare localization of extrarenal nephroblastoma in 1-month-old female infant. J Pediatr Urol. 2012;8(4):e43-5. http://dx.doi.org/10.1016/j.jpurol.2012.03.005. PMid:22465824.

8 Wu Y, Zhu X, Wang X, Wang H, Cao X, Wang J. Extrarenal nephroblastomatosis in children: a report of two cases. BMC Pediatr. 2014;14(1):255. http://dx.doi.org/10.1186/1471-2431-14-255. PMid:25288411.

9 Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study. Cancer. 1978;41(5):1937-48. http://dx.doi.org/10.1002/1097-0142(197805)41:5<1937::AID-CNCR2820410538>3.0.CO;2-U. PMid:206343.

10 D’Hooghe E, Mifsud W, Vujanić GM. “Teratoid” Wilms Tumor: The extreme end of heterologous element differentiation, not a separate entity. Am J Surg Pathol. 2019;43(11):1583-90. http://dx.doi.org/10.1097/PAS.0000000000001335. PMid:31600178.

11 Fernandes ET, Parham DM, Ribeiro RC, Douglass EC, Mahesh Kumar AP, Wilimas J. Teratoid Wilms’ tumor: the St Jude experience. J Pediatr Surg. 1988;23(12):1131-4. http://dx.doi.org/10.1016/S0022-3468(88)80328-2. PMid:2853218.

12 Shojaeian R, Hiradfar M, Sharifabad PS, Zabolinejad N. Extrarenal Wilms’ Tumor: challenges in diagnosis, embryology, treatment and prognosis. In: van den Heuvel-Eibrink MM, editor. Wilms tumor. Brisbane: Codon Publications; 2016. Chap. 6.

13 Madanat F, Osborne B, Cangir A, Sutow WW. Extrarenal Wilms tumor. J Pediatr. 1978;93(3):439-43. http://dx.doi.org/10.1016/S0022-3476(78)81153-6. PMid:211216.

Submitted date:
02/25/2022

Accepted date:
06/01/2022

Publication date:
07/15/2022

Primary Wilms tumor of the urinary bladder

Mayur Parkhi; Srinivasan Peyam; Nitin James Peters; Kushaljit Singh Sodhi; Amita Trehan; Amanjit Bal

Abstract

Keywords

References

Links

Share

Autops Case Rep