Myeloid sarcoma in the tongue

Bernar Monteiro Benites; Felipe Paiva Fonseca; Wanessa Miranda-Silva; Julia Stephanie Bruno; Luciana Tucunduva; Eduardo Rodrigues Fregnani

doi:10.4322/acr.2020.160

Article / Clinical Case Report

Myeloid sarcoma in the tongue

Bernar Monteiro Benites; Felipe Paiva Fonseca; Wanessa Miranda-Silva; Julia Stephanie Bruno; Luciana Tucunduva; Eduardo Rodrigues Fregnani

http://dx.doi.org/10.4322/acr.2020.160 Autops Case Rep, vol.10, n2, e2020160, 2020

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Abstract

Leukemic cells are rarely present in the oral cavity, and there are very few reports regarding such cases. However, we identified some reports of leukemic cells infiltrating tissues in the oral cavity, including gingival involvement. Recurrent painful oral ulcerations and prominent generalized periodontal destruction are the most common oral features of neutrophil disorders, and they may even be the initial symptoms of the disease. The ulcers may affect any part of the oral mucosa, including the tongue and palate. The objective of this report is to describe and discuss a case of myeloid sarcoma in the oral cavity of a 48-year-old male patient.

Keywords

Leukemia, Medical Oncology, Pathology, Oral, Oral Medicine

References

Swerdlow SH, Campo E, Harris NL, et al.

WHO classification of tumours of haematopoietic and lymphoid tissues: 2. Genebra: WHO; 2017.

Dineshkumar T, Suresh V, Ramya R, Rajkumar K. Primary intraoral granulocytic sarcoma: a rare case presenting as generalized gingival enlargement.

J Oral Maxillofac Pathol. 2016;20(3):523-6. [https://doi.org/10.4103/0973-029X.190958]. [PMID:27721621]

Jinbu Y, Naito H, Noguchi T, Akasaka Y, Ozawa K. Unusual tumor formation in the tongue of an acute myelocytic leukemia patient: report of a case.

Oral Med & Pathol. 2000;5(1):53-6. [https://doi.org/10.3353/omp.5.53].

Noone A-M, Cronin KA, Altekruse SF, et al. Cancer incidence and survival trends by subtype using data from the surveillance epidemiology and end results program, 1992-2013.

Cancer Epidemiol Biomarkers Prev. 2017;26(4):632-41. [https://doi.org/10.1158/1055-9965.EPI-16-0520]. [PMID:27956436]

Jinbu Y, Naito H, Noguchi T, Akasaka Y, Ozawa K. Unusual tumor formation in the tongue of an acute myelocytic leukemia patient: report of a case.

Oral Med. Pathol. 2000;5(1):53-6. [https://doi.org/10.3353/omp.5.53].

Gomez RS, Duarte ECB, Guimarães ALS, et al. B-leukemic infiltrate in palate.

Oral Oncol Extra. 2004;40(3):54-7. [https://doi.org/10.1016/j.ooe.2004.02.002].

Hasan, S., Khan, N. I. & Reddy, L. B. Leukemic gingival enlargement: report of a rare case with review of literature. 2015;5(1):65-7. [https://doi.org/10.4103/2229-516X.149251]. [PMID:25664273].

Tirali RE, Yalcinkaya Erdemci Z, Cehreli SB. Oral findings and clinical implications of patients with congenital neutropenia: a literature review.

Turk J Pediatr. 2013;55(3):241-5. [PMID:24217068]

Brasil. Ministério da Saúde, Instituto Nacional de Câncer José Alencar Gomes da Silva.

Estimativa 2018-Incidência de câncer no Brasil. Brasília: Ministério da Saúde; 2017.

Zimmermann C, Meurer MI, Grando LJ, Gonzaga Del Moral JÂ, da Silva Rath IB, Schaefer Tavares S. Dental treatment in patients with leukemia.

J Oncol. 2015;2015:571739. [https://doi.org/10.1155/2015/571739]. [PMID:25784937]

Jordan RCK, Glenn L, Treseler PA. Granulocytic sarcoma: case report with an unusual presentation and review of the literature.

J Oral Maxilofac Surg. 2002;60(10):1206-11. [https://doi.org/10.1053/joms.2002.35036].

Kirnbauer B, Wölfler A, Sill H, Beham A, Prettenhofer U, Jakse N. Myeloid sarcoma in the oral cavity.

Int J Stomatol Occlusion Med. 2013;6(2):65-9. [https://doi.org/10.1007/s12548-012-0071-6].

Stafford R, Sonis S, Lockhart P, Sonis A. Oral pathoses as diagnostic indicators in leukemia.

Oral Surg Oral Med Oral Pathol. 1980;50(2):134-9. [https://doi.org/10.1016/0030-4220(80)90200-5]. [PMID:6967202]

Dreizen S, McCredie KB, Keating MJ, Luna MA. Malignant gingival and skin ‘infiltrates’ in adult leukemia.

Oral Surg Oral Med Oral Pathol. 1983;55(6):572-9. [https://doi.org/10.1016/0030-4220(83)90373-0]. [PMID:6576290]

Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.

J Clin Oncol. 1995;13(7):1800-16. [https://doi.org/10.1200/JCO.1995.13.7.1800]. [PMID:7602369]

Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia Working Parties.

Blood. 1998;92(7):2322-33. [https://doi.org/10.1182/blood.V92.7.2322]. [PMID:9746770]

Schoch C, Kern W, Schnittger S, Hiddemann W, Haferlach T. Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML.

Leukemia. 2004;18(1):120-5. [https://doi.org/10.1038/sj.leu.2403187]. [PMID:14586477]

Visani G, Loscocco F, Isidori A, Piccaluga PP. Genetic profiling in acute myeloid leukemia: a path to predicting treatment outcome.

Expert Rev Hematol. 2018;11(6):455-61. [https://doi.org/10.1080/17474086.2018.1475225]. [PMID:29792762]

Yap M, Hewson I, McLean C, Ciciulla J. Oral myeloid sarcoma: two case reports.

Aust Dent J. 2014;59(4):511-5. [https://doi.org/10.1111/adj.12220]. [PMID:25159834]

Ignacio-Cconchoy FL, Benites-Zapata VA, Yanac-Avila RL, Vela-Velàsquez CT. Myeloid sarcoma of the tongue as a first manifestation of acute promyelocytic leukemia: a case report.

Rep Pract Oncol Radiother. 2020;25(2):174-7. [https://doi.org/10.1016/j.rpor.2019.12.026]. [PMID:32021572]

Publication date:
05/06/2020

Myeloid sarcoma in the tongue

Bernar Monteiro Benites; Felipe Paiva Fonseca; Wanessa Miranda-Silva; Julia Stephanie Bruno; Luciana Tucunduva; Eduardo Rodrigues Fregnani

Abstract

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References

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