Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2024.476
Autopsy and Case Reports
Clinical Case Report

Primary leiomyosarcoma with osteosarcomatous differentiation of the breast

Ekta Sethi; Sunayana Misra; Arvind Ahuja

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Abstract

Primary leiomyosarcoma with osteosarcomatous differentiation of the breast is an uncommon entity. We present the case of a 37-year-old female who presented with a lump in the breast and pulmonary lesions on PET-CT, for which she underwent a toilet mastectomy. Histopathological examination revealed a tumor with cells arranged in sheets. These tumor cells had moderate eosinophilic cytoplasm, highly pleomorphic, irregular hyperchromatic nuclei, coarse chromatin, and prominent nucleoli. Areas with spindle-cell morphology were noted. Osteoid was seen intermingling with the tumor along with numerous osteoclast-like multinucleate giant cells. A wide panel of Immunohistochemistry was applied, and Desmin, h-Caldesmon, SMA, and Vimentin were positive. The patient died 3 months post-surgery and had a recurrence at the surgical site.

Keywords

Breast, Leiomyosarcoma, Mastectomy, Sarcoma

References

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Submitted date:
01/09/2024

Accepted date:
01/31/2024

Publication date:
02/26/2024

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