Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2023.453
Autopsy and Case Reports
Clinical Case Report and Review

Biliary adenofibroma: a precursor lesion of intrahepatic cholangiocarcinoma

Mayur Parkhi; Rashmi Joshi; Manish Kumar; Aditi Sharma; Suvradeep Mitra; Lileswar Kaman

Downloads: 0
Views: 272

Abstract

Biliary adenofibroma (BAF) is an uncommon liver tumor with a high propensity for malignant transformation. The histomorphology of BAF with malignant transformation can show a spectrum of changes ranging from benign, dysplastic to frank malignancy. Thus, the diagnosis of BAF imposes the pursuit of dysplasia/ malignancy focus. We presented a case of intrahepatic cholangiocarcinoma arising from BAF in a 49-year-old woman with detailed histomorphology. We also performed a PubMed database search and tabulated all previously reported cases of BAF with dysplasia/ malignant transformation. A statistic comparison of age, sex ratio, size of the tumor, and survival following complete resection between BAFs with and without dysplasia/ malignancy from the retrieved data is presented. Our analysis did not highlight any statistically significant difference between BAFs with and without dysplasia/ malignancy in age, sex ratio, tumor size, and survival following complete surgical resection. Our study highlights the histopathology and immunohistochemistry of a case of BAF with malignant transformation and highlights the importance of this diagnosis in management. Further longitudinal studies on a larger cohort of patients are required to validate our findings.

Keywords

Liver, Biliary Tract, Adenofibroma, Cholangiocarcinoma

References

1 Tsui WM, Loo KT, Chow LT, Tse CC. Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver. Am J Surg Pathol. 1993;17(2):186-92. http://dx.doi.org/10.1097/00000478-199302000-00010. PMid:8422113.

2 Arnason T, Borger DR, Corless C, et al. Biliary adenofibroma of liver: morphology, tumor genetics, and outcomes in 6 cases. Am J Surg Pathol. 2017;41(4):499-505. http://dx.doi.org/10.1097/PAS.0000000000000773. PMid:28266931.

3 Wang SC, Chen YY, Cheng F, Wang HY, Wu FS, Teng LS. Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: a case report. World J Clin Cases. 2022;10(25):9104-11. http://dx.doi.org/10.12998/wjcc.v10.i25.9104. PMid:36157634.

4 Hu W, Zhao Y, Liu Y, Hua Z, Liu A. Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review. BMC Med Imaging. 2022;22(1):47. http://dx.doi.org/10.1186/s12880-022-00775-9. PMid:35296268.

5 Haberal AN, Bilezikci B, Demirhan B, Karakayali H, Haberal M. Malignant transformation of biliary adenofibroma: a case report. Turk J Gastroenterol. 2001;12:149-53.

6 Akin O, Coskun M. Biliary adenofibroma with malignant transformation and pulmonary metastases: CT findings. AJR Am J Roentgenol. 2002;179(1):280-1. http://dx.doi.org/10.2214/ajr.179.1.1790280. PMid:12076957.

7 Nguyen NT, Harring TR, Holley L, Goss JA, O’Mahony CA. Biliary adenofibroma with carcinoma in situ: a rare case report. Case Reports Hepatol. 2012;2012:793963. http://dx.doi.org/10.1155/2012/793963. PMid:25374710.

8 Thai E, Dalla Valle R, Evaristi F, Silini EM. A case of biliary adenofibroma with malignant transformation. Pathol Res Pract. 2016;212(5):468-70. http://dx.doi.org/10.1016/j.prp.2015.12.015. PMid:26778388.

9 Godambe A, Brunt EM, Fulling KH, Reza Kermanshahi T. Biliary adenofibroma with invasive carcinoma: case report and review of the literature. Case Rep Pathol. 2016;2016:8068513. http://dx.doi.org/10.1155/2016/8068513. PMid:26885426.

10 Thompson SM, Zendejas-Mummert B, Hartgers ML, et al. Malignant transformation of biliary adenofibroma: a rare biliary cystic tumor. J Gastrointest Oncol. 2016;7(6):E107-12. http://dx.doi.org/10.21037/jgo.2016.09.14. PMid:28078134.

11 Kaminsky P, Preiss J, Sasatomi E, Gerber DA. Biliary adenofibroma: a rare hepatic lesion with malignant features. Hepatology. 2017;65(1):380-3. http://dx.doi.org/10.1002/hep.28818. PMid:27631648.

12 Chua D, Chiow AKH, Ang TL, Wang LM. Malignant transformation arising within unusual and rare hepatic lesions: fibropolycystic disease form of ductal plate malformation and biliary adenofibroma. Int J Surg Pathol. 2018;26(6):542-50. http://dx.doi.org/10.1177/1066896918758172. PMid:29464972.

13 Sturm AK, Welsch T, Meissner C, Aust DE, Baretton G. A case of biliary adenofibroma of the liver with malignant transformation: a morphomolecular case report and review of the literature. Surg Case Rep. 2019;5(1):104. http://dx.doi.org/10.1186/s40792-019-0661-2. PMid:31236706.

14 Lim HJ, Park MS, Park YN, Kim SI, Kim YE, Hwang CH. A case report of cholangiocarcinoma arising from a biliary adenofibroma: radiologic findings and review of literature. Taehan Yongsang Uihakhoe Chi. 2021;82(3):721-8. http://dx.doi.org/10.3348/jksr.2020.0043. PMid:36238782.

15 Alshbib A, Grzyb K, Syversveen T, Reims HM, Lassen K, Yaqub S. Biliary adenofibroma: a rare liver tumor with transition to invasive carcinoma. Case Rep Surg. 2022;2022:5280884. http://dx.doi.org/10.1155/2022/5280884. PMid:35178267.

16 Ahuja N, Mitra S, Bal A, Das A, Tandup C, Krishnaraju VS. Multiple biliary adenofibromas with Adenocarcinoma of Gallbladder: histopathological Conundrum. J Gastrointest Cancer. 2022 [Online ahead of print]. http://dx.doi.org/10.1007/s12029-022-00857-5. PMid:36048315.

17 Kai K, Yakabe T, Kohya N, et al. A case of unclassified multicystic biliary tumor with biliary adenofibroma features. Pathol Int. 2012;62(7):506-10. http://dx.doi.org/10.1111/j.1440-1827.2012.02830.x. PMid:22726072.

18 Tsutsui A, Bando Y, Sato Y, et al. Biliary adenofibroma with ominous features of imminent malignant changes. Clin J Gastroenterol. 2014;7(5):441-8. http://dx.doi.org/10.1007/s12328-014-0523-1. PMid:26184026.

19 Jacobs MA, Lanciault C, Weinstein S. Incidental biliary adenofibroma with dysplastic features. BJR Case Rep. 2015;1(2):20150100. http://dx.doi.org/10.1259/bjrcr.20150100. PMid:30363187.

20 Liu SR, Zhu Q, Feng MB, Yan Q, Zhu TF, Xu LB. Atypical biliary adenofibroma of the liver: related treatment and performance. Case Rep Gastroenterol. 2022;16(2):535-45. http://dx.doi.org/10.1159/000526196. PMid:36157605.

21 Agarwal J, Patkar S, Rabade K, Bal M, Goel M. Intrahepatic Cholangiocarcinoma in a background of biliary adenofibroma: a rare entity. J Gastrointest Cancer. 2023 [Online ahead of print]. http://dx.doi.org/10.1007/s12029-023-00931-6. PMid:36995560.

22 Kanemaru N, Nakai Y, Watadani T, et al. Multimodal imaging findings of intrahepatic cholangiocarcinoma arising from a biliary adenofibroma: a case report with radiological-pathological correlation. Abdom Radiol. 2023;48(8):2469-76. http://dx.doi.org/10.1007/s00261-023-03908-y. PMid:37074475.
 


Submitted date:
07/11/2023

Accepted date:
09/24/2023

Publication date:
11/13/2023

65523367a9539530802e3f53 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections