Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

Signet ring cell carcinoma of the rectal stump in a known ulcerative colitis patient

Asmanaz Nadaf; Ibrahim Hassan Al Haddabi; Ramesh Babu Telugu; Mansour S Al Moundhri

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Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer worldwide and is the second most common cause of cancer-related deaths. However, the Omani population shares the major burden as the most prevalent carcinoma. The disease is comparatively higher in males than females. Patients with pre-existing risk factors, including inflammatory bowel disease, are at increased risk of developing neoplasia. Among the various histopathological subtypes of adenocarcinoma in the rectum, signet ring cell carcinoma is the rarest and accounts for approximately 1% of the cases. Given the aggressive nature of this tumor, advanced presentation, stage, and poor prognosis, regular endoscopic surveillance is essential. Hereby, we report a rare case of signet ring cell carcinoma arising in the rectal stump in an already diagnosed and operated patient of Ulcerative colitis.


Colon, Carcinoma, Ulcerative Colitis, surveillance, Rectum


1 Greuter T, Vavricka S, König A, Beaugerie L, Scharl M, Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology. Malignancies in inflammatory bowel disease. Digestion. 2020;101(suppl 1):136-45. PMid:32799195.

2 Farraj FA, Sabbagh H, Aridi T, Fakhruddin N, Farhat F. Signet ring cell carcinoma of the colon in young adults: a case report and literature review. Case Rep Oncol Med. 2019;2019:3092674. PMid:31612089.

3 Kumar S, Burney IA, Zahid KFD, et al. Colorectal cancer patient characteristics, treatment and survival in oman--a single center study. Asian Pac J Cancer Prev. 2015;16(12):4853-8. PMid:26163603.

4 de Campos Silva EF, Baima JP, de Barros JR, et al. Risk factors for ulcerative colitis-associated colorectal cancer: a retrospective cohort study. Medicine (Baltimore). 2020;99(32):e21686. PMid:32769938.

5 Sunkara C, Swanson G, Forsyth CB, Keshavarzian A. Chronic inflammation and malignancy in ulcerative colitis. Ulcers, 2011;2011:714046.

6 Nitsche U, Zimmermann A, Späth C, et al. Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg. 2013;258(5):775-82, discussion 782-3. PMid:23989057.

7 Fornaro R, Caratto M, Caratto E, et al. Colorectal cancer in patients with inflammatory bowel disease: the need for a real surveillance program. Clin Colorectal Cancer. 2016;15(3):204-12. PMid:27083409.

8 Hamilton SR, Aaltonen LA. WHO Classification of Tumours. Digestive System tumors. 5th ed. Lyon: IARC Press; 2019. p. 105-25.

9 Ishii H, Hata K, Kishikawa J, et al. Incidence of neoplasias and effectiveness of postoperative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis. World J Surg Oncol. 2016;14:75. PMid:26960982.

10 Belli S, Aytac HO, Karagulle E, Yabanoglu H, Kayaselcuk F, Yildirim S. Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature. Int Surg. 2014;99(6):691-8. PMid:25437572.

11 Khan O, Ligato S. Identification of signet ring cell change in colonic subserosa in the setting of clostridium difficile colitis. Int J Surg Pathol. 2017;25(2):168-72. PMid:27562801.

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