Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2021.338
Autopsy and Case Reports
Clinical Case Report and Review

Mucosal Schwann cell hamartoma of the gallbladder

Farhan Ismael; Sidrah Khawar; Ameer Hamza

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Abstract

Mucosal Schwann cell hamartoma (MSCH) is a rare benign neurogenic tumor characterized by pure S100p positive spindle cell proliferation. Most cases occur in the distal colon. Involvement of the gall bladder is exceedingly rare. There have been no reports of recurrence or a syndromic association with MSCH. Herein, we describe a case of MSCH of the gallbladder in a 55-year-old female patient with prior history of gastrointestinal neurofibromas who presented with abdominal pain. MR imaging revealed choledocholithiasis, gallbladder thickening, and marked biliary and pancreatic ductal dilation. The patient subsequently underwent cholecystectomy with choledochoduodenostomy. Histologic evaluation of the gallbladder showed diffuse expansion of the mucosa with S100p positive cells with spindly nuclei and indistinct cytoplasmic borders and diagnosis of MSCH of the gallbladder was rendered.

Keywords

Schwann cells, Hamartoma, Neurofibroma, Neuroma, Gallbladder, MSCH

References

1 Gibson JA, Hornick JL. Mucosal Schwann cell “hamartoma”: clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. Am J Surg Pathol. 2009;33(5):781-7. http://dx.doi.org/10.1097/PAS.0b013e31818dd6ca. PMid:19065103.

2 Bae MN, Lee JE, Bae SM, et al. Mucosal schwann-cell hamartoma diagnosed by using an endoscopic snare polypectomy. Ann Coloproctol. 2013;29(3):130-4. http://dx.doi.org/10.3393/ac.2013.29.3.130. PMid:23862132.

3 Sharma K, Dhua AK, Goel P, Jain V, Yadav DK, Ramteke P. Mucosal schwann cell hamartoma of the gall bladder. J Indian Assoc Pediatr Surg. 2021;26(3):182-3. http://dx.doi.org/10.4103/jiaps.JIAPS_45_20. PMid:34321790.

4 Khanna G, Ghosh S, Barwad A, Yadav R, Das P. Mucosal Schwann cell hamartoma of gall bladder: a novel observation. Pathology. 2018;50(4):480-2. http://dx.doi.org/10.1016/j.pathol.2017.11.095. PMid:29739615.

5 Hytiroglou P, Petrakis G, Tsimoyiannis EC. Mucosal Schwann cell hamartoma can occur in the stomach and must be distinguished from other spindle cell lesions. Pathol Int. 2016;66(4):242-3. http://dx.doi.org/10.1111/pin.12376. PMid:26778643.

6 Li Y, Beizai P, Russell JW, Westbrook L, Nowain A, Wang HL. Mucosal Schwann cell hamartoma of the gastroesophageal junction: a series of 6 cases and comparison with colorectal counterpart. Ann Diagn Pathol. 2020;47:151531. http://dx.doi.org/10.1016/j.anndiagpath.2020.151531. PMid:32460039.

7 Han J, Chong Y, Kim TJ, Lee EJ, Kang CS. Mucosal schwann cell hamartoma in colorectal mucosa: a rare benign lesion that resembles gastrointestinal neuroma. J Pathol Transl Med. 2017;51(2):187-9. http://dx.doi.org/10.4132/jptm.2016.07.02. PMid:27560153.

8 Pasquini P, Baiocchini A, Falasca L, et al. Mucosal Schwann cell “Hamartoma”: a new entity? World J Gastroenterol. 2009;15(18):2287-9. http://dx.doi.org/10.3748/wjg.15.2287. PMid:19437573.

9 Kizil C, Kyritsis N, Brand M. Effects of inflammation on stem cells: together they strive? EMBO Rep. 2015;16(4):416-26. http://dx.doi.org/10.15252/embr.201439702. PMid:25739812.

10 Doyle LA, Hornick JL. Mesenchymal tumors of the gastrointestinal tract other than GIST. Surg Pathol Clin. 2013;6(3):425-73. http://dx.doi.org/10.1016/j.path.2013.05.003. PMid:26839096.
 


Submitted date:
09/10/2021

Accepted date:
09/27/2021

Publication date:
10/22/2021

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