Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report and Review

Congenital thymoma

Momal Tara Chand; Jacob Edens; Tayson Taixin Lin; David Goshorn; Truc Pham

Downloads: 1
Views: 918


Thymomas are a heterogeneous group of tumors arising from the epithelium of the thymus. They are categorized by the proportion of neoplastic epithelia to lymphocytes and by the degree of cytologic atypia. Thymomas constitute 0.2-1.5% of all malignancies and nearly all occur in patients over 20 years. We reviewed the available literature and found less than 50 cases of thymoma reported in children (<18 years of age), the youngest being 4 years old, and no cases in newborns. They represent less than 1% of all mediastinal tumors in children. Due to the limited number of cases in the pediatric population, the diagnosis and treatment in this population is extremely challenging. Thymomas in all age groups may be associated with paraneoplastic syndromes, being myasthenia gravis the most common, which is associated with a worse prognosis in the pediatric population. We present the first case of a newborn infant with congenital thymoma. This case demonstrates a rare tumor in an unusual age group and emphasizes the importance of multidisciplinary teamwork in the decision-making and management of this condition.


Congenital Abnormalities, Hospitals, Pediatric, Thymoma, Thymus Hyperplasia, Thymus Neoplasms


1 Safieddine N, Liu G, Cuningham K, et al. Prognostic factors for cure, recurrence and long-term survival after surgical resection of thymoma. J Thorac Oncol. 2014;9(7):1018-22. PMid:24926546.

2 Coulter D, Gold S. Thymoma in the offspring of a patient with Isaacs syndrome. J Pediatr Hematol Oncol. 2007;29(11):797-8. PMid:17984702.

3 Stachowicz-Stencel T, Orbach D, Brecht I, et al. Thymoma and thymic carcinoma in children and adolescents: a report from the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT). Eur J Cancer. 2015;51(16):2444-52. PMid:26259494.

4 Carretto E, Inserra A, Ferrari A, et al. Epithelial thymic tumours in paediatric age: a report from the TREP project. Orphanet J Rare Dis. 2011;6(1):28. PMid:21600006.

5 Weissferdt A, Kalhor N, Bishop JA, et al. Thymoma: a clinicopathological correlation of 1470 cases. Hum Pathol. 2018;73:7-15. PMid:28851660.

6 Guleria P, Jain D. Thymic lesions of the paediatric age group: a comprehensive review of non-neoplastic and neoplastic etiologies. Mediastinum. 2019;3:24.

7 Falkson CB, Bezjak A, Darling G, et al. The management of thymoma: a systematic review and practice guideline. J Thorac Oncol. 2009;4(7):911-9. PMid:19557895.

8 Nishino M, Ashiku SK, Kocher ON, Thurer RL, Boiselle PM, Hatabu H. The thymus: a comprehensive review. Radiographics. 2006;26(2):335-48. PMid:16549602.

9 Evoli A, Minicuci GM, Vitaliani R, et al. Paraneoplastic diseases associated with thymoma. J Neurol. 2007;254(6):756-62. PMid:17325820.

10 Jung KJ, Lee KS, Han J, Kim J, Kim TS, Kim EA. Malignant thymic epithelial tumors: CT-pathologic correlation. AJR Am J Roentgenol. 2001;176(2):433-9. PMid:11159089.

11 Liang X, Lovell MA, Capocelli KE, et al. Thymoma in children: report of 2 cases and review of the literature. Pediatr Dev Pathol. 2010;13(3):202-8. PMid:20055684.

Submitted date:

Accepted date:

Publication date:

614b62a8a95395330641d474 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections