Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report and Review

Primary malignant giant cell tumor of the sternum

Mohammed Imaduddin; Pavithra Ayyanar; Mahesh Sultania; Dillip Muduly; Mukund Namdev Sable; Suprava Naik; Sambit Mohanty; Madhabananda Kar

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Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.


Neoplasms, Giant cell tumors, Sternum


1 Palmerini E, Picci P, Reichardt P, Downey G. Malignancy in giant cell tumor of bone: a review of the literature. Technol Cancer Res Treat. 2019;18. PMid:30935298.

2 Dahlin DC, Cupps RE, Johnson EW Jr. Giant-cell tumor: a study of 195 cases. Cancer. 1970;25(5):1061-70.<1061::AID-CNCR2820250509>3.0.CO;2-E. PMid:4910256.

3 Unni KK, Inwards CY, Bridge JA, Kindblom LG, Wold LE. Tumors of the bones and joints. In: Armed Forces Institute of Pathology (AFIP). Atlas of tumor pathology: series 4. Washington: AFIP; 2005.

4 van der Heijden L, Dijkstra PDS, van de Sande MAJ, et al. The clinical approach toward giant cell tumor of bone. Oncologist. 2014;19(5):550-61. PMid:24718514.

5 Stewart FW, Coley BL, Farrow JH. Malignant giant cell tumor of bone. Am J Pathol. 1938;14(5):515-36. PMid:19970407.

6 Jaffe HL. Giant cell tumor of bone. Its pathologic appearance, grading, supposed variants and treatment. Arch Path. 1940;30(5):993-1031.

7 Hutter RVP, Worcester JN, Francis KC, Foote FW, Stewart FW. Benign and malignant giant cell tumors of bone: a clinicopathological analysis of the natural history of the disease. Cancer. 1962;15(4):653-90.<653::AID-CNCR2820150402>3.0.CO;2-M. PMid:14450279.

8 Nascimento AG, Huvos AG, Marcove RC. Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. Cancer. 1979;44(4):1393-402.<1393::AID-CNCR2820440433>3.0.CO;2-Z. PMid:227563.

9 Bathurst N, Sanerkin N, Watt I. Osteoclast-rich osteosarcoma. Br J Radiol. 1986;59(703):667-73. PMid:3460667.

10 Engel EE, Nogueira-Barbosa MH, Yamashita ME, Cipriano FE, Valera ET, Brassesco MS. Clinical and cytogenetic aspects of giant cell tumor of the sternum. Clinics. 2011;66(8):1501-4. PMid:21915509.

11 Anract P, De Pinieux G, Cottias P, Pouillart P, Forest M, Tomeno B. Malignant giant-cell tumours of bone: clinico-pathological types and prognosis: a review of 29 cases. Int Orthop. 1998;22(1):19-26. PMid:9549577.

12 Lin J-L, Wu Y-H, Shi Y-F, et al. Survival and prognosis in malignant giant cell tumor of bone: a population-based analysis from 1984 to 2013. J Bone Oncol. 2019;19:100260. PMid:31667061.

13 Sundaram M, Martin SA, Johnson FE, Wolverson MK. Case report 198: giant cell tumor of manubrium. Skeletal Radiol. 1982;8(3):225-7. PMid:7112152.

14 Bay JO, Bignon YJ, Gros P, et al. Giant cell tumor of the sternum. Report of a case with a 17q isochromosome. Rev Rhum Engl Ed. 1999;66(1):49-52. PMid:10036700.

15 Segawa T, Kanamori M, Ohmori K, et al. Giant cell tumor of the sternum: a case report. J Orthop Sci. 2004;9(2):175-7. PMid:15045548.

16 Imai K, Minamiya Y, Saito H, Kawai H, Ito M, Ogawa J. Giant cell tumor of the sternum. Jpn J Thorac Cardiovasc Surg. 2006;54(9):405-8. PMid:17037398.

17 Futani H, Okumura Y, Fukuda Y, Fukunaga S, Hasegawa S, Yoshiya S. Giant cell tumor of the sternum: a case report and review of the literature. Anticancer Res. 2008;28(6B):4117-20. PMid:19192670.

18 Abate E, Banki F, Hagen JA, Klipfel N. Giant cell tumor of the sternum. Ann Thorac Surg. 2009;88(2):645-7. PMid:19632429.

19 Faria RA, Silva CM, Miziara JEA, Melo FY, Silva SRM, Viana CR. Giant cell tumor of the sternum. J Bras Pneumol. 2010;36(4):517-20. PMid:20835602.

20 Traibi A, Boulahya A, Ihrai H, Oukabli M, El Kabiri H. Giant cell tumors that originated in the sternum. Gen Thorac Cardiovasc Surg. 2011;59(2):148-51. PMid:21308447.

21 Wang Y, Feng W, Chu XY, Yang B, Zhao M, Sun Y. Sternum bone giant cell tumor resection and chest wall reconstruction after the excision of breast cancer. J Cancer Res Ther. 2015;11(3):661. PMid:26458679.

22 Muramatsu K, Tani Y, Seto T, et al. Two cases with giant cell tumor arising from the sternum: diagnosis and options for treatment. J Orthop Sci. 2020. PMid:32001081.

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