Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report and Review

Gangliocytic paraganglioma of the spine

Shubha Lal; Ishita Pant; Sujata Chaturvedi; Pragyan Sarma

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Paragangliomas are rare, encapsulated, benign neuroendocrine tumors that can arise from the adrenal medulla or extra-adrenal paraganglia. Extra-adrenal paragangliomas may develop a gangliocytic component with ganglion cells (Gangliocytic paragangliomas). Nearly 25%of cauda equina paragangliomas are gangliocytic paragangliomas. Here, we describe the case of a 35-year-old male who presented with weakness of both lower limbs over the last two months. Radiological findings were suggestive of myxopapillary ependymoma. However, the histopathological examination revealed a tumor with cells arranged in sheets, papillae, lobules, and around vessels forming pseudo rosettes. Ganglion cells were seen in small groups and, also singly. Tumor cells were immunopositive for chromogranin, synaptophysin, and S-100. Ganglion cells were immunopositive for synaptophysin, NSE, and NFP. A final histological diagnosis of Gangliocytic paraganglioma (WHO grade I) was made. To date, only nine gangliocytic paraganglioma cases have been previously reported, and to the best of our knowledge, this is the largest gangliocytic paraganglioma.


gangliocytic paraganglioma, spine


1 Akbik OS, Floruta C, Chohan MO, SantaCruz KS, Carlson AP. A unique case of an aggressive gangliocytic paraganglioma of the filum terminale. Case Rep Surg. 2016;2016:1232594. PMid:27433367.

2 Vural M, Arslantas A, Isiksoy S, Adapinar B, Atasoy M, Soylemezoglu F. Gangliocytic paraganglioma of the cauda equina with significant calcification: first description in pediatric age. Zentralbl Neurochir. 2008;69(1):47-50. PMid:18393166.

3 Nagose VB, Jadhav VA. Gangliocytic paraganglioma of dorsolumbar spine: a rare tumor at rare site. Asian J Neurosurg. 2019;14(3):907-10. PMid:31497126.

4 Llena JF, Wisoff HS, Hirano A. Gangliocytic paraganglioma in cauda equina region, with biochemical and neuropathological studies: case report. J Neurosurg. 1982;56(2):280-2. PMid:7054439.

5 Mishra T, Goel AN, Goel AH. Primary paraganglioma of the spine: a clinicopathological study of eight cases. J Craniovertebr Junction Spine. 2014;5(1):20-4. PMid:25013343.

6 Moran CA, Rush W, Mena H. Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of 30 cases. Histopathology. 1997;31(2):167-73. PMid:9279569.

7 Caruso R, Wierzbicki V, Marrocco L, Salvati M. Paragangliomas of the cauda equina. Report of one case and review of the literature. J Exp Clin Cancer Res. 2006;25(2):269-75. PMid:16918140.

8 Scheithauer BW, Brandner S, Soffer D. Spinal paraganglioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO classification of tumours of the central nervous system. Lyon: IARC; 2007. p. 117-9.

9 Matschke J, Westphal M, Lamszus K. November 2004: intradural mass of the cauda equina in a woman in her early 60s. Brain Pathol. 2005;15(2):169-70. PMid:15912890.

10 Djindjian M, Ayache P, Brugieres P, Malapert D, Baudrimont M, Poirier J. Giant gangliocytic paraganglioma of the filum terminale: case report. J Neurosurg. 1990;73(3):459-61. PMid:2384785.

11 Olsen WL, Dillon WP, Kelly WM, Norman D, Brant-Zawadzki M, Newton TH. MR imaging of paragangliomas. AJR Am J Roentgenol. 1987;148(1):201-4. PMid:3024473.

12 Suri V, Singh PK, Garg A, et al. Gangliocytic paraganglioma of filum terminale: report of a rare case. Neurol India. 2014;62(5):543-5. PMid:25387626.

13 Gelabert-González M. Paragangliomas of the lumbar region: report of two cases and review of the literature. J Neurosurg Spine. 2005;2(3):354-65. PMid:15796363.

14 Yin M, Huan Q, Sun Z, et al. clinical characteristics and surgical treatment of spinal paraganglioma: a case series of 18 patients. Clin Neurol Neurosurg. 2017;158:20-6. PMid:28433725.

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