Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2020.235
Autopsy and Case Reports
Clinical Case Report

Synchronous eyelid oncocytoma and conjunctival intraepithelial neoplasia

Zachariah Chowdhury; Benjamin Nongrum; Chandana Rajbongshi

Downloads: 0
Views: 794

Abstract

ABSTRACT: Oncocytoma of the eyelid is a rare neoplasm. Oncocytoma associated with an ocular surface squamous neoplasm, namely conjunctival intraepithelial neoplasia, is very hard to find in the literature. Herein we report a case of a 53-year-old male who presented with a swelling in the right lower lid over the last 6 years, along with a growth in the conjunctiva of the same eye for the last 2 years and encroaching upon the cornea for the last 4 months. Excision biopsy of the lower lid mass showed histopathological features consistent with oncocytoma. The conjunctival tissue revealed conjunctival intraepithelial neoplasia 3 (severe dysplasia). This case documents a rare synchronous dual ocular neoplasia, a very unlikely coexistence of oncocytoma with conjunctival intraepithelial neoplasia.

Keywords

Eyelid Neoplasms, Papilloma, Pterygium

References

1 Biggs SL, Font RL. Oncocytic lesions of the caruncle and other ocular adnexa. Arch Ophthalmol. 1977;95(3):474-8. http://dx.doi.org/10.1001/archopht.1977.04450030116017. PMid:843279.

2 Østergaard J, Prause JU, Heegaard S. Oncocytic lesions of the ophthalmic region: a clinicopathological study with emphasis on cytokeratin expression. Acta Ophthalmol. 2011;89(3):263-7. http://dx.doi.org/10.1111/j.1755-3768.2009.01677.x. PMid:19843013.

3 Riedel K, Stefani FH, Kampik A. Oncocytoma of the ocular adnexa. Klin Monatsbl Augenheilkd. 1983;182(6):544-8. http://dx.doi.org/10.1055/s-2008-1054850. PMid:6876649.

4 Thaller VT, Collin JR, McCartney AC. Oncocytoma of the eyelid: a case report. Br J Ophthalmol. 1987;71(10):753-6. http://dx.doi.org/10.1136/bjo.71.10.753. PMid:3676144.

5 Østergaard J, Prause JU, Heegaard S. Caruncular lesions in Denmark 1978-2002: a histopathological study with correlation to clinical referral diagnosis. Acta Ophthalmol Scand. 2006;84(1):130-6. http://dx.doi.org/10.1111/j.1600-0420.2005.00543.x. PMid:16445453.

6 Fenelon EM, Balby IT, Neves NTD, Figueiredo F, Duarte ECB, Tzelikis PF. Oncocytoma of the lacrimal gland: a case report. Arq Bras Oftalmol. 2017;80(2):128-30. http://dx.doi.org/10.5935/0004-2749.20170031. PMid:28591289.

7 Cameron JR, Barras CW. Oncocytoma of the eyelid. Acta Ophthalmol Scand. 2005;83(1):125. http://dx.doi.org/10.1111/j.1600-0420.2005.00346.x. PMid:15715577.

8 Al-Mohtaseb Z, Lee S, Yen MT. Oncocytoma of the upper conjunctival fornix. Eye Rep. 2011;1(7):17-9.

9 Rodgers IR, Jakobiec FA, Krebs W, Hornblass A, Gingold MP. Papillary oncocytoma of the eyelid. A previously undescribed tumor of apocrine gland origin. Ophthalmology. 1988;95(8):1071-6. http://dx.doi.org/10.1016/S0161-6420(88)33068-X. PMid:2852788.

10 Fukuo Y, Hirata H, Takeda N, Hayami H, Katayama T. A case of oncocytoma in the eyelid. Ophthalmologica. 1994;208(1):54-7. http://dx.doi.org/10.1159/000310452. PMid:8145989.

11 Mittal R, Rath S, Vemuganti GK. Ocular surface squamous neoplasia – Review of etiopathogenesis and an update on clinic-pathological diagnosis. Saudi J Ophthalmol. 2013;27(3):177-86. http://dx.doi.org/10.1016/j.sjopt.2013.07.002. PMid:24227983.

12 Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET. Human papillomavirus infection and ocular surface disease. Int J Oncol. 2019;54(5):1503-10. http://dx.doi.org/10.3892/ijo.2019.4755. PMid:30896784.

13 Ateenyi-Agaba C. Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda. Lancet. 1995;345(8951):695-6. http://dx.doi.org/10.1016/S0140-6736(95)90870-6. PMid:7885126.

14 Newton R, Ferlay J, Reeves G, Beral V, Parkin DM. Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye. Lancet. 1996;347(9013):1450-1. http://dx.doi.org/10.1016/S0140-6736(96)91685-2. PMid:8676629.

15 Reidy JJ, Bouchard CS, Florakis GJ, et al. Basic and clinical science course. San Francisco: American Academy of Ophthalmology. p. 226-33.

16 Oellers P, Karp CL, Sheth A, et al. Prevalence, treatment, and outcomes of coexistent ocular surface squamous neoplasia and pterygium. Ophthalmology. 2013;120(3):445-50. http://dx.doi.org/10.1016/j.ophtha.2012.08.010. PMid:23107578.

17 Say EA, Shields CL, Bianciotto C, Eagle RC Jr, Shields J. Oncocytic lesions (oncocytoma) of the ocular adnexa: report of 15 cases and review of literature. Ophthal Plast Reconstr Surg. 2012;28(1):14-21. http://dx.doi.org/10.1097/IOP.0b013e31822dd236. PMid:21956543.

18 Shields JA, Eagle RC, Marr BP, Shields CL, Grossniklaus HE, Stulting RD. Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. Cornea. 2007;26(8):1014-6. http://dx.doi.org/10.1097/ICO.0b013e3180cfe80e. PMid:17721310.

19 Roy A, Rath S, Das S, Vemuganti GK, Parulkar G. Penetrating sclerokeratoplasty in massive recurrent invasive squamous cell carcinoma. Ophthal Plast Reconstr Surg. 2011;27(2):e39-40. http://dx.doi.org/10.1097/IOP.0b013e3181eea1d4. PMid:20871462.

20 Shields CL, Demirci H, Marr BP, Masheyekhi A, Materin M, Shields JA. Chemoreduction with topical mitomycin C prior to resection of extensive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol. 2005;123(1):109-13. http://dx.doi.org/10.1001/archopht.123.1.109. PMid:15642823.

21 Hӧllhumer R, Williams S, Michelow P. Observational study of ocular surface squamous neoplasia: risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa. PLoS One. 2020;15(8):e0237453. http://dx.doi.org/10.1371/journal.pone.0237453. PMid:32780766.

22 Cicinelli MV, Marchese A, Bandello F, Modorati G. Clinical management of ocular surface squamous neoplasia: a review of the current evidence. Ophthalmol Ther. 2018;7(2):247-62. http://dx.doi.org/10.1007/s40123-018-0140-z. PMid:30030703.

23 Shields CL, Chien JL, Surakiatchanukul T, Sioufi K, Lally SE, Shields JA. Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes- the 2017 J. Donald M. Gass lecture. Asia Pac J Ophthalmol. 2017;6(2):109-20. PMid:28399347.

24 Maskin SL. Regression of limbal epithelial dysplasia with topical interferon. Arch Ophthalmol. 1994;112(9):1145-6. http://dx.doi.org/10.1001/archopht.1994.01090210029007. PMid:8085957.

25 Karp CL, Moore JK, Rosa RH Jr. Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon α-2b. Ophthalmology. 2001;108(6):1093-8. http://dx.doi.org/10.1016/S0161-6420(01)00577-2. PMid:11382635.
 


Submitted date:
05/23/2020

Accepted date:
09/30/2020

Publication date:
01/28/2021

60131aba0e88256d3f045c66 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections