Autopsy and Case Reports
Autopsy and Case Reports
Autopsy Case Report and Review

ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature

Kaniyappan Nambiyar; Kirti Gupta; Uma Debi; Saroj Kant Sinha; Rakesh Kochhar

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ABSTRACT: Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with the near replacement of the myocardial wall by the neoplastic cells was observed. A total of nine isolated case reports of anaplastic large cell lymphoma with cardiac involvement were found in the English-language literature, and a widespread cardiac and thymic infiltration by the systemic ALK-positive anaplastic large cell lymphoma has not been documented. An incidental regenerative nodule was also identified in the liver. The patient died of pulmonary thromboembolism and cardiac arrest.


Lymphoma, Large-cell, Anaplastic, Anaplastic lymphoma kinase, Heart, Thymus Gland, Thromboembolism


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