Autopsy and Case Reports
Autopsy and Case Reports
Autopsy Case Report and Review

A rare presentation of Sinonasal Undifferentiated Carcinoma with brain metastasis and para-aortic mass

Sujata Sarangi; Sudeep Khera; Vikarn Vishwajeet; Vikas Meshram; Puneet Setia; Abhishek Malik

Downloads: 4
Views: 1030


ABSTRACT: Sinonasal Undifferentiated carcinoma (SNUC) comprises 3% of the head and neck tumors, including metastatic neoplasms. Herein we report the case of a 60-year-old male who was brought dead to our institute with previous records of a contrast-enhanced CT scan of the brain and MRI with evidence of tumor in the maxillary sinus with intracranial extensions. The histopathological examination of the mass in the maxillary sinus proved to be SNUC with metastases to the brain, lungs, and around the aorta. These tumors are undifferentiated and are distinct from other poorly differentiated tumors in deriving their origin from the Schneiderian epithelium. The aggressive nature of the tumor renders the prognosis quite dismal. SNUCs need to be early recognized and distinguished from other poorly differentiated carcinomas with the help of immunohistochemistry.


Maxillary Sinus, Sinonasal undifferentiated Carcinoma, Metastasis


1 Goel R, Ramalingam K, Ramani P, Chandrasekar T. Sino nasal undifferentiated carcinoma: a rare entity. J Nat Sci Biol Med. 2012;3(1):101-4. PMid:22690063.

2 Frierson HF Jr, Mills SE, Fechner RE, Taxy JB, Levine PA. Sinonasal undifferentiated carcinoma: an aggressive neoplasm derived from Schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 1986;10(11):771-2. PMid:2430477.

3 Abdelmeguid AS, Bell D, Hanna EY. Sinunasal undifferentiated carcinoma. Curr Oncol Rep. 2019;21(3):26. PMid:30806835.

4 Ejaz A, Wenig BM. Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol. 2005;12(3):134-43. PMid:15900114.

5 Rischin D, Porceddu S, Peters L, Martin J, Corry J, Weih L. Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck. 2004;26(5):435-41. PMid:15122660.

6 Edwards PC, Hess SJ, Saini T. Sinonasal undifferentiated carcinoma of the maxillary sinus. J Can Dent Assoc. 2006;72(2):163-7. PMid:16545179.

7 Jeng YM, Sung MT, Fang CL, et al. Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. Am J Surg Pathol. 2002;26(3):371-6. PMid:11859210.

8 Hunt J. Immunohistology of head and neck neoplasms. In: Dabbs DJ, editor. Diagnostic immunohistochemistry theranostic and genomic applications. Philadelphia: Elsevier; 2011.

9 Enepekides DJ. Sinonasal undifferentiated carcinoma: an update. Curr Opin Otolaryngol Head Neck Surg. 2005;13(4):222-5. PMid:16012246.

10 El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumors. 4th ed. Lyon: IARC; 2017.

11 Agaimy A, Franchi A, Lund VJ, et al. Sinonasal undifferentiated carcinoma (SNUC): from an entity to morphologic pattern and back again-a historical perspective. Adv Anat Pathol. 2020;27(2):51-60. PMid:31876536.

12 Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304-16. PMid:31661314.

13 Agaimy A, Weichert W. SMARCA4-deficient sinonasal carcinoma. Head Neck Pathol. 2017;11(4):541-5. PMid:28176137.

14 Xu CC, Dziegielewski PT, McGaw WT, Seikaly H. Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. J Otolaryngol Head Neck Surg. 2013;42(1):2. PMid:23663264.

15 Tyler MA, Holmes B, Patel ZM. Oncologic management of sinonasal undifferentiated carcinoma. Curr Opin Otolaryngol Head Neck Surg. 2019;27(1):59-66. PMid:30507692.

Submitted date:

Accepted date:

Publication date:

5fb81c6d0e88252011093a73 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections