Autopsy and Case Reports
Autopsy and Case Reports
Original Article

Dystrophic muscle distribution in late-stage muscular dystrophy

Celeste Michelle Pilato; Melissa Sue Walker; Andrea M. Nguyen; McKay Elizabeth Hanna; Scott Lanxing Huang; Erika Morgan Lutins; M. Alex Meredith; Peter Jacob Haar; Mathula Thangarajh; Hope Theresa Richard; Woon Nam Chow

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ABSTRACT: There is scant information about the comprehensive distribution of dystrophic muscles in muscular dystrophy. Despite different clinical presentations of muscular dystrophy, a recent multi-center study concluded that phenotypic distribution of dystrophic muscles is independent of clinical phenotype and suggested that there is a common pattern of involved muscles. To evaluate this possibility, the present case report used cadaveric dissection to determine the whole-body distribution of fat-infiltrated, dystrophic muscles from a 72-year-old white male cadaver with adult-onset, late-stage muscular dystrophy. Severely dystrophic muscles occupied the pectoral, gluteal and pelvic regions, as well as the arm, thigh and posterior leg. In contrast, muscles of the head, neck, hands and feet largely appeared unaffected. Histopathology and a CT-scan supported these observations. This pattern of dystrophic muscles generally conformed with that described in the multi-center study, and provides prognostic insight for patients and the physicians treating them.


Muscular Dystrophies, Musculoskeletal System, Cadaver, Muscular Dystrophy, Limb-Girdle


1 Theadom A, Rodrigues M, Roxburgh R, et al. Prevalence of muscular dystrophies: a systematic literature review. Neuroepidemiology. 2014;43(3-4):259-68. PMid:25532075.

2 Brancaccio A. A molecular overview of the primary dystroglycanopathies. J Cell Mol Med. 2019;23(5):3058-62. PMid:30838779.

3 Mercuri E, Muntoni F. Muscular dystrophies. Lancet. 2013;381(9869):845-60. PMid:23465426.

4 Bushby KM. Dysferlin and muscular dystrophy. Acta Neurol Belg. 2000;100(3):142-5. PMid:11098285.

5 Diaz-Manera J, Fernandez-Torron R, LLauger J, et al. Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials. J Neurol Neurosurg Psychiatry. 2018;89(10):1071-81. PMid:29735511.

6 Umakhanova ZR, Bardakov SN, Mavlikeev MO, et al. Twenty-year clinical progression of dysferlinopathy in patients from dagestan. Front Neurol. 2017;8:77. PMid:28337173.

7 Waldrop MA, Flanigan KM. Update in Duchenne and Becker muscular dystrophy. Curr Opin Neurol. 2019;32(5):722-7. PMid:31343429.

8 National Institute of Dental and Craniofacial Research – NIDCR. Human subjects research overview [Internet]. 2020 [cited 2020 May 26]. Available from:

9 Saito M, Kawai H, Adachi K, Akaike M. Clinical feature and mechanism of cardiac failure in patients with Becker muscular dystrophy. Rinsho Shinkeigaku. 1994;34(2):134-40. PMid:8194265.

10 Nigro G, Comi LI, Politano L, Bain RJ. The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy. Int J Cardiol. 1990;26(3):271-7. PMid:2312196.

11 McDonald CM, Abresch RT, Carter GT, Fowler WM Jr, Johnson ER, Kilmer DD. Profiles of neuromuscular diseases. Becker’s muscular dystrophy. Am J Phys Med Rehabil. 1995;74(5, Suppl):S93-103. PMid:7576425.

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