Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2020.210
Autopsy and Case Reports
Short Communication

Oral lichen planus and HCV infection

Jefferson R. Tenório; Alessandra Rodrigues de Camargo; Celso Lemos; Karem L. Ortega

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Abstract

ABSTRACT: Chronic infection by hepatitis C virus (HCV) can lead not only to the development of hepatic cirrhosis, but also to the emergence of extra-hepatic manifestations (EHMs), such as oral lichen planus (OLP). Here, we describe a clinical presentation of massive, erosive OLP in an HCV-positive patient whose clinical management was difficult. Full remission was achieved after sustained virological response by using direct-acting anti-retrovirals. This case report demonstrates not only the importance of diagnosing EHMs for identification of HCV infection, but also the importance of controlling it for management of OLP and EHMs.

Keywords

Hepatitis C, Chronic, Lichen Planus, Oral

References

1 Naggie S, Hepatitis C. Virus, Inflammation, and Cellular Aging: Turning Back Time. Top Antivir Med. 2017;25(1):3-6. PMid:28402927.

2 Negro F, Forton D, Craxi A, Sulkowski MS, Feld JJ, Manns MP. Extrahepatic morbidity and mortality of chronic hepatitis C. Gastroenterology. 2015;149(6):1345-60. http://dx.doi.org/10.1053/j.gastro.2015.08.035. PMid:26319013.

3 Viganò M, Colombo M. Extrahepatic Manifestations of Hepatitis C Virus. Gastroenterol Clin North Am. 2015;44(4):775-91. http://dx.doi.org/10.1016/j.gtc.2015.07.006. PMid:26600219.

4 Carrozzo M, Scally K. Oral manifestations of hepatitis C virus infection. World J Gastroenterol. 2014;20(24):7534-43. http://dx.doi.org/10.3748/wjg.v20.i24.7534. PMid:24976694.

5 Carrozzo M, Thorpe R. Oral lichen planus: a review. Minerva Stomatol. 2009;58(10):519-37. PMid:19893476.

6 Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009;48(7):682-94. http://dx.doi.org/10.1111/j.1365-4632.2009.04062.x. PMid:19570072.

7 Mokni M, Rybojad M, Puppin D Jr, et al. Lichen planus and hepatitis C virus. J Am Acad Dermatol. 1991;24(5):792. http://dx.doi.org/10.1016/S0190-9622(08)80376-3. PMid:1651354.

8 Oliveira Alves MG, Almeida JD, Guimarães Cabral LA. Association between hepatitis C virus and oral lichen planus: HCV and oral Lichen Planus. Hepat Mon. 2011;11(2):132-3. PMid:22087133.

9 Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. ScientificWorldJournal. 2014;2014:742826. http://dx.doi.org/10.1155/2014/742826. PMid:24672362.

10 Yokozeki H, Niiyama S, Nishioka K. Twenty-nail dystrophy (trachyonychia) caused by Lichen Planus in a patient with gold allergy. Br J Dermatol. 2005;152(5):1087-9. http://dx.doi.org/10.1111/j.1365-2133.2005.06581.x. PMid:15888190.

11 Larrubia JR, Moreno-Cubero E, Lokhande MU, et al. Adaptive immune response during hepatitis C virus infection. World J Gastroenterol. 2014;20(13):3418-30. http://dx.doi.org/10.3748/wjg.v20.i13.3418. PMid:24707125.

12 Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A. Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol. 2010;52(3):315-21. http://dx.doi.org/10.1016/j.jhep.2009.12.013. PMid:20129690.

13 Farid C, Sheikh WE, Swelem R, El-Ghitany E. Frequency of FOXP3+ Regulatory T-cells in the Blood of Chronic Hepatitis C Patients with Immune Mediated Skin Manifestations; Relationship to Hepatic Condition and Viral Load. Clin Lab. 2016;62(12):2339-48. http://dx.doi.org/10.7754/Clin.Lab.2016.160421. PMid:28164561.

14 Shu Y, Hu Q, Long H, Chang C, Lu Q, Xiao R. Epigenetic Variability of CD4+CD25+ Tregs Contributes to the Pathogenesis of Autoimmune Diseases. Clin Rev Allergy Immunol. 2017;52(2):260-72. http://dx.doi.org/10.1007/s12016-016-8590-3. PMid:27687891.

15 Tao JH, Cheng M, Tang JP, Liu Q, Pan F, Li XP. Foxp3, Regulatory T Cell, and Autoimmune Diseases. Inflammation. 2017;40(1):328-39. http://dx.doi.org/10.1007/s10753-016-0470-8. PMid:27882473.

16 Carrozzo M, Gandolfo S, Carbone M, et al. Hepatitis C virus infection in Italian patients with oral lichen planus: a prospective case-control study. J Oral Pathol Med. 1996;25(10):527-33. http://dx.doi.org/10.1111/j.1600-0714.1996.tb01726.x. PMid:8986963.

17 Sánchez-Pérez J, Castro M, Buezo GF, Herrera JF, Borque MJ, García-Diez A. Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection. Br J Dermatol. 1996;134(4):715-9. http://dx.doi.org/10.1111/j.1365-2133.1996.tb06977.x. PMid:8733378.

18 Lei L, Zhan L, Tan W, Chen S, Li Y, Reynolds M. Foxp3 gene expression in oral lichen planus: a clinicopathological study. Mol Med Rep. 2014;9(3):928-34. http://dx.doi.org/10.3892/mmr.2014.1919. PMid:24469541.

19 Lorenzini G, Viviano M, Chisci E, Chisci G, Picciotti M. A comparative immunohistochemical and immunophenotypical study on lymphocytes expression in patients affected by oral lichen planus. J Oral Pathol Med. 2013;42(8):642-7. http://dx.doi.org/10.1111/jop.12058. PMid:23495733.

20 Nagao Y, Sata M, Ide T, et al. Development and exacerbation of oral lichen planus during and after interferon therapy for hepatitis C. Eur J Clin Invest. 1996;26(12):1171-4. http://dx.doi.org/10.1046/j.1365-2362.1996.610607.x. PMid:9013095.

21 Nagao Y, Kawaguchi T, Ide T, Kumashiro R, Sata M. Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C. Int J Mol Med. 2005;15(2):237-41. http://dx.doi.org/10.3892/ijmm.15.2.237. PMid:15647837.

22 Grossmann SM, Teixeira R, Aguiar MC, Carmo MA. Exacerbation of oral lichen planus lesions during treatment of chronic hepatitis C with pegylated interferon and ribavirin. Eur J Gastroenterol Hepatol. 2008;20(7):702-6. http://dx.doi.org/10.1097/MEG.0b013e3282f1cc5d. PMid:18679075.

23 Sise ME, Bloom AK, Wisocky J, et al. Treatment of hepatitis C virus-associated mixed cryoglobulinemia with direct-acting antiviral agents. Hepatology. 2016;63(2):408-17. http://dx.doi.org/10.1002/hep.28297. PMid:26474537.

24 Mazzaro C, Dal Maso L, Quartuccio L, et al. Long-term effects of the new direct antiviral agents (DAAs) therapy for HCV-related mixed cryoglobulinaemia without renal involvement: a multicentre open-label study. Clin Exp Rheumatol 2018;36(2 Suppl 111):107-14. PMID: 29465371.

25 Yoshikawa A, Terashita K, Morikawa K, et al. Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: acase report. Clin J Gastroenterol. 2017;10(3):270-3. http://dx.doi.org/10.1007/s12328-017-0742-3. PMid:28447325.

26 Misaka K, Kishimoto T, Kawahigashi Y, Sata M, Nagao Y. Use of direct-acting antivirals for the treatment of hepatitis C virus-associated oral lichen planus: a case report. Case Rep Gastroenterol. 2016;10(3):617-22. http://dx.doi.org/10.1159/000450679. PMid:27920651.

27 Nagao Y, Kimura K, Kawahigashi Y, Sata M. Successful treatment of hepatitis C virus-associated oral lichen planus by interferon-free therapy with direct-acting antivirals. Clin Transl Gastroenterol. 2016;7(7):e179. http://dx.doi.org/10.1038/ctg.2016.37. PMid:27388424.

28 Comarmond C, Garrido M, Pol S, et al. Direct-acting antiviral therapy restores immune tolerance to patients with hepatitis C virus-induced cryoglobulinemia vasculitis. Gastroenterology. 2017;152(8):2052-2062.e2. http://dx.doi.org/10.1053/j.gastro.2017.02.037. PMid:28274850.

29 Mester A, Lucaciu O, Ciobanu L, Apostu D, Ilea A, Campian RS. Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP. Bosn J Basic Med Sci. 2018;18(3):217-23. http://dx.doi.org/10.17305/bjbms.2018.3133. PMid:29984679.

30 Wiznia LE, Laird ME, Franks AG Jr. Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era. J Eur Acad Dermatol Venereol. 2017;31(8):1260-70. http://dx.doi.org/10.1111/jdv.14186. PMid:28252812.
 


Submitted date:
06/11/2020

Accepted date:
07/28/2020

Publication date:
11/20/2020

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