Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

Full recovery of a stage IV cancer patient facing COVID-19 pandemic

Anuraj Parmanande; Diana Simão; Mariana Sardinha; Ana Filipa Palma dos Reis; Ana Sofia Spencer; João Vasco Barreira; Ricardo da Luz

Downloads: 2
Views: 1224


Coronavirus disease 2019 (COVID-19), first recognized in Wuhan, China, was recently declared a global pandemic by the World Health Organization (WHO). Advanced age and comorbid disease, well-known characteristics in the solid tumor population, have been reported as risk factors for severe disease and death. Cancer-related immunosuppression and its treatments also seem to play an active role in the prognosis, response, and clinical outcomes of these patients. The most effective combination therapy for COVID-19 is still under investigation, and the use of corticosteroids is controversial. Although, as a group, metastatic cancer patients are often considered not to be good candidates for ICU treatment, the individual prognosis should always come into consideration, even in a context of high pressure on medical facilities. We report the case of a stage IV prostate cancer patient infected with SARS-CoV-2 who required ICU admission and recovered from COVID-19 infection. Further studies are needed in order to identify accurate clinical prognostic criteria and provide the best treatment for these challenging patients.


COVID-19, SARS-CoV-2, Cancer, Critical care, Treatment Outcome


World Health Organization (WHO).


Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance. Vol.1-2. Geneva: WHO; 2020. p. 1-21.


Liang W, Guan W, Chen R, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China.



Lancet Oncol. 2020;21(3):335-7. []. [PMID:32066541]


Kamboj M, Sepkowitz KA. Nosocomial infections in patients with cancer.



Lancet Oncol. 2009;10(6):589-97. []. [PMID:19482247]


Li JY, Duan XF, Wang LP, et al. Selective depletion of regulatory t cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer.



J Immunol Res. 2014;2014:286170. []. [PMID:24868562]


Rodriguez-Morales A, Cardona-Ospina J, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis.



Travel Med Infect Dis. 2020;34:101623. []. [PMID:32179124]


Direção-Geral da Saúde (DGS).



Doença pelo novo Coronavírus (COVID-19) – Nova definição de caso. Lisboa: DGS; 2020. Orientação 02/2020 atualizada em 09/03/2020.


Zhang L, Zhu F, Xie L, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China.



Ann Oncol. 2020; pii: S0923-7534(20):36383-3. [Epub ahead of print]. [].


Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy.



JAMA. 2020. []. [PMID:32203977]


Schellongowski P, Sperr WR, Wohlfarth P, et al. Critically ill patients with cancer: chances and limitations of intensive care medicine — a narrative review.



ESMO Open. 2016;1(1):1-6. []. [PMID:27843637]


Martins RM, Teixeira G, Cortesão E, et al.



Recomendações para tratamento médico intensivo em doentes oncológicos. Lisboa: Sociedade Portuguesa de Oncologia; 2020.


Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review.



JAMA. 2020. [Epub ahead of print]. []. [PMID:32282022]


Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China.



JAMA Intern Med. 2020. [Epub ahead of print]. []. [PMID:32167524]


Gautret P, Lagier J-C, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.



Inten J Antimicrob Agents. 2020. [Epub ahead of print]. [].


Sheahan TP, Sims AC, Leist SR, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.



Nat Commun, 11:222. [].


Mendes JJ, Mergulhão P, Froes F, Paiva JA, Gouveia J. Recommendations from the Sociedade Portuguesa de Cuidados Intensivos and Infection & Sepsis Group for intensive care approach to COVID-19.



Rev Bras Ter Intensiva. 2020;32(1):2-10. [PMID:32401989]












































Publication date:

5eda92c50e8825ab2a1dab04 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections