Autopsy and Case Reports
https://www.autopsyandcasereports.org/article/doi/10.4322/acr.2020.162
Autopsy and Case Reports
Article / Autopsy Case Report

Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma

Yu Miyama; Takeshi Fujii; Kyoko Murase; Hisashi Takaya; Fukuo Kondo

Downloads: 5
Views: 1091

Abstract

Hepatoid adenocarcinoma of the lung is a rare subtype of lung cancer. We report a case of a metastatic hepatoid adenocarcinoma of the lung with aggressive behavior, including biopsy and autopsy findings. The pulmonary tumors showed features indistinguishable from hepatocellular carcinoma and were diffusely positive for Hepatocyte Paraffin 1.

Keywords

Adenocarcinoma, Hepatoid carcinoma, Hepatocellular carcinoma, Non-small cell carcinoma,

References

Yan BC, Gong C, Song J, et al. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.

 

 

 

Am J Surg Pathol. 2010;34(8):1147-54. [https://doi.org/10.1097/PAS.0b013e3181e5dffa]. [PMID:20661013]

 

 

 

Che YQ, Wang S, Luo Y, Wang JB, Wang LH. Hepatoid adenocarcinoma of the lung: presenting mediastinal metastasis without transfer to the liver.

 

 

 

 

 

 

Oncol Lett. 2014;8(1):105-10. [https://doi.org/10.3892/ol.2014.2064]. [PMID:24959228]

 

 

 

Motooka Y, Yoshimoto K, Semba T, et al. Pulmonary hepatoid adenocarcinoma: report of a case.

 

 

 

 

 

 

Surg Case Rep. 2016;2(1):1. [https://doi.org/10.1186/s40792-016-0129-6]. [PMID:26943677]

 

 

 

Mokrim M, Belbaraka R, Allaoui M, et al. Hepatoid Adenocarcinoma of the Lung: A Case Report and Literature Review.

 

 

 

 

 

 

J Gastrointest Cancer. 2012;43(Suppl 1):S125-7. [https://doi.org/10.1007/s12029-011-9318-5]. [PMID:21894458]

 

 

 

Haninger DM, Kloecker GH, Bousamra M 2nd, Nowacki MR, Slone SP. Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature.

 

 

 

 

 

 

Mod Pathol. 2014;27(4):535-42. [https://doi.org/10.1038/modpathol.2013.170]. [PMID:24030743]

 

 

 

Grossman K, Beasley MB, Braman SS. Hepatoid adenocarcinoma of the lung: review of a rare form of lung cancer.

 

 

 

 

 

 

Respir Med. 2016;119:175-9. [https://doi.org/10.1016/j.rmed.2016.09.003]. [PMID:27692141]

 

 

 

Sun JN, Zhang BL, Li LK, Yu HY, Wang B. Hepatoid adenocarcinoma of the lung without production of alpha-fetoprotein: a case report and review of the literature.

 

 

 

 

 

 

Oncol Lett. 2016;12(1):189-94. [https://doi.org/10.3892/ol.2016.4559]. [PMID:27347123]

 

 

 

Papatsimpas G, Kamposioras K, Goula K, et al. Hepatoid pancoast tumor: a case report and review of the literature.

 

 

 

 

 

 

Lung Cancer. 2012;77(2):239-45. [https://doi.org/10.1016/j.lungcan.2012.05.102]. [PMID:22677427]

 

 

 

Gavrancic T, Park YH. A novel approach using sorafenib in alpha fetoprotein-producing hepatoid adenocarcinoma of the lung.

 

 

 

 

 

 

J Natl Compr Canc Netw. 2015;13(4):387-91, quiz 91. [https://doi.org/10.6004/jnccn.2015.0054]. [PMID:25870375]

 

 

 

Shaib W, Sharma R, Mosunjac M, Farris AB 3rd, El Rayes B. Hepatoid adenocarcinoma of the lung: a case report and review of the literature.

 

 

 

 

 

 

J Gastrointest Cancer. 2014;45(Suppl 1):99-102. [https://doi.org/10.1007/s12029-013-9558-7]. [PMID:24408270]

 

 

 

Miyake M, Ito M, Mitsuoka A, et al. Alpha-fetoprotein and human chorionic gonadotropin-producing lung cancer.

 

 

 

 

 

 

Cancer. 1987;59(2):227-32. [https://doi.org/10.1002/1097-0142(19870115)59:2<227::AID-CNCR2820590209>3.0.CO;2-X]. [PMID:2433015]

 

 

 

Hayashi Y, Takanashi Y, Ohsawa H, Ishii H, Nakatani Y. Hepatoid adenocarcinoma in the lung.

 

 

 

 

 

 

Lung Cancer. 2002;38(2):211-4. [https://doi.org/10.1016/S0169-5002(02)00214-3]. [PMID:12399135]

 

 

 

Hiroshima K, Iyoda A, Toyozaki T, et al. Alpha-fetoprotein-producing lung carcinoma: report of three cases.

 

 

 

 

 

 

Pathol Int. 2002;52(1):46-53. [https://doi.org/10.1046/j.1440-1827.2002.01311.x]. [PMID:11940206]

 

 

 

Kishimoto T, Yano T, Hiroshima K, Inayama Y, Kawachi K, Nakatani Y. A case of α-fetoprotein–producing pulmonary carcinoma with restricted expression of hepatocyte nuclear factor-4α in hepatoid foci: a case report with studies of previous cases.

 

 

 

 

 

 

Hum Pathol. 2008;39(7):1115-20. [https://doi.org/10.1016/j.humpath.2007.12.013]. [PMID:18570977]

 

 

 

Lin SF, Hsu WH, Chou TY. Primary pulmonary hepatoid carcinoma: report of a case and review of the literature.

 

 

 

 

 

 

Kaohsiung J Med Sci. 2013;29(9):512-6. [https://doi.org/10.1016/j.kjms.2013.01.007]. [PMID:24018156]

 

 

 

Terracciano LM, Glatz K, Mhawech P, et al. Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases.

 

 

 

 

 

 

Am J Surg Pathol. 2003;27(10):1302-12. [https://doi.org/10.1097/00000478-200310000-00002]. [PMID:14508391]

 

 

 

Valle L, Thomas J, Kim C, et al. Hepatoid adenocarcinoma of the lung metastasizing to the tonsil.

 

 

 

 

 

 

Mol Clin Oncol. 2017;6(5):705-7. [https://doi.org/10.3892/mco.2017.1215]. [PMID:28529745]

 

 

 

Basse V, Schick U, Gueguen P, et al. A mismatch repair-deficient hepatoid adenocarcinoma of the lung responding to Anti-PD-L1 durvalumab therapy despite no PD-L1 expression.

 

 

 

 

 

 

J Thorac Oncol. 2018;13(7):e120-2. [https://doi.org/10.1016/j.jtho.2018.03.004]. [PMID:29935850]

 

 

 

Arnould L, Drouot F, Fargeot P, et al. Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein-producing lung tumor.

 

 

 

 

 

 

Am J Surg Pathol. 1997;21(9):1113-8. [https://doi.org/10.1097/00000478-199709000-00018]. [PMID:9298890]

 

 

 

Ishikura H, Kanda M, Ito M, Nosaka K, Mizuno K. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma.

 

 

 

 

 

 

Virchows Arch A Pathol Anat Histopathol. 1990;417(1):73-80. [https://doi.org/10.1007/BF01600112]. [PMID:1694332]

 

 

 

Fan Z, van de Rijn M, Montgomery K, Rouse RV. Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.

 

 

 

 

 

 

Mod Pathol. 2003;16(2):137-44. [https://doi.org/10.1097/01.MP.0000052103.13730.20]. [PMID:12591966]

 

 

 

Pan CC, Chen PC, Tsay SH, Chiang H. Cytoplasmic immunoreactivity for thyroid transcription factor-1 in hepatocellular carcinoma: a comparative immunohistochemical analysis of four commercial antibodies using a tissue array technique.

 

 

 

 

 

 

Am J Clin Pathol. 2004;121(3):343-9. [https://doi.org/10.1309/8BM44NK626997DJJ]. [PMID:15023038]

 

 

 

Gu K, Shah V, Ma C, Zhang L, Yang M. Cytoplasmic immunoreactivity of thyroid transcription factor-1 (clone 8G7G3/1) in hepatocytes: true positivity or cross-reaction?

 

 

 

 

 

 

Am J Clin Pathol. 2007;128(3):382-8. [https://doi.org/10.1309/CADCVWHR2QF6JMVN]. [PMID:17709311]

 

 

 

Carlinfante G, Foschini MP, Pasquinelli G, Scotti R, Cavazza A. Hepatoid carcinoma of the lung: a case report with immunohistochemical, ultrastructural and in-situ hybridization findings.

 

 

 

 

 

 

Histopathology. 2000;37(1):88-9. [https://doi.org/10.1046/j.1365-2559.2000.00955-5.x]. [PMID:10931226]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Publication date:
04/02/2020

5e85f1d60e88256122a14d48 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections