Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

Unusual abscess masquerading as poorly differentiated adenocarcinoma of the colon showing characteristics of choriocarcinoma

Antigony Mitselou; Anna Varouktsi; Stamatis S. Papadatos; Eugenia Balasi; Evangeli Lampri; Konstantinos Katsanos; Vasiliki Galani

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Extragonadal non-gestational choriocarcinoma (ENC) is an uncommon malignant tumor occasionally found in the gastrointestinal tract. ENC is characterized by a biphasic tumor growth with distinct areas of adenocarcinoma and choriocarcinoma differentiation. Primary choriocarcinoma of the colon is extremely rare, with only 21 cases reported in the literature. Most of the perforation of colorectal cancers occurs in the abdominal cavity, while abdominal wall abscess is rare; the psoas abscess associated with colon carcinoma is even less observed. Herein, we report the case of a 61-year-old female with poorly differentiated adenocarcinoma of the ascending colon and sigmoid, with choriocarcinomatous differentiation, masquerading a psoas abscess formation. Unfortunately, despite the aggressive therapy, the patient’s disease rapidly progressed, and she died within 2 months after the diagnosis. The typical morphological pattern, immunohistochemistry, and its correlation with serum β-human chorionic gonadotropin enabled a correct diagnosis.


Adenocarcinoma, Choriocarcinoma, Abscess, Colon, Extragonadal Nongestational Choriocarcinoma


Le DT, Austin RC, Payne SN, Dworkin MJ, Chappell ME. Choriocarcinoma of the colon. A case report and review of the literature.








Dis Colon Rectum. 2003;46(2):264-6. []. [PMID:12576901]








Jiang L, Wu JT, Peng X. Primary choriocarcinoma of the colon: a case report and review of the literature.















World J Surg Oncol. 2013;11(1):23-7. []. [PMID:23356395]








Park CH, Reid JD. Adenocarcinoma of the colon with choriocarcinoma in its metastases.















Cancer. 1980;46(3):570-5. [<570::AID-CNCR2820460325>3.0.CO;2-Y]. [PMID:7190461]








Nguyen GK. Adenocarcinoma of the sigmoid colon with focal choriocarcinoma metaplasia: a case report.















Dis Colon Rectum. 1982;25(3):230-4. []. [PMID:7200001]








Oh SK, Kim HW, Kang DH, et al. Primary adenocarcinoma with focal choriocarcinomatous differentiation in the sigmoid colon.















Korean J Gastroenterol. 2015;66(5):291-6. []. [PMID:26586354]








Okita A, Kubo Y, Tanada M, Kurita A, Takashima S. Unusual abscesses associated with colon cancer: report of three cases.















Acta Med Okayama. 2007;61(2):107-13. [PMID:17471312]








Peterson CM, Allison JG, Lu CC. Psoas abscess resulting from perforating carcinoma of the sigmoid colon. A case report.















Dis Colon Rectum. 1983;26(6):390-2. []. [PMID:6851800]








Kourda N, Bettaieb I, Blel A, et al. An aggressive course of de novo ulcerative colitis after renal transplantation: colonic adenocarcinoma with choriocarcinomatous differentiation.















Tunis Med. 2009;87(5):359-61. [PMID:19927772]








Ordóñez NG, Luna MA. Choriocarcinoma of the colon.















Am J Gastroenterol. 1984;79(1):39-42. [PMID:6362401]








Kubosawa H, Nagao K, Kondo Y, Ishige H, Inaba N. Coexistence of adenocarcinoma and choriocarcinoma of the sigmoid colon.















Cancer. 1984;54(5):866-8. [<866::AID-CNCR2820540518>3.0.CO;2-U]. [PMID:6540137]








Metz KA, Richter HJ, Leder LD. Adenocarcinoma of the colon with syncytiotrophoblastic differentiation: differential diagnosis and implications.















Pathol Res Pract. 1985;179(3):419-24. []. [PMID:4039056]








Lind HM, Haghighi P. Carcinoembryonic antigen staining in choriocarcinoma.















Am J Clin Pathol. 1986;86(4):538-40. []. [PMID:2429544]








Ostör AG, McNaughton WM, Fortune DW, Rischin D, Hillcoat BL, Riley CB. Rectal adenocarcinoma with germ cell elements.















Pathology. 1993;25(3):243-6. []. [PMID:7505421].








Tokisue H, Yasutake K, Oya M, et al. Coexistence of choriocarcinoma and adenocarcinoma in the rectum: molecular aspects.















J Gastroenterol. 1996;31(3):431-6. []. [PMID:8726837]








Oh YH, Lee WM, Kim KS, Park MH, Lee JD. Composite adenocarcinoma and choriocarcinoma of the sigmoid colon with hepatic metastasis of the choriocarcinomatous component.















Korean J Pathol. 1997;31:788-93.








Kim YM, Cho MY, Hong SW, Jung SH. Choriocarcinoma of the colon.















Korean J Pathol. 1997;31:794-7.








Kiran RP, Visvanathan R, Simpson CG. Choriocarcinomatous metaplasia of a metachronous adenocarcinoma of the colon.















Eur J Surg Oncol. 2001;27(4):436-7. []. [PMID:11417994]








Verbeek W, Schulten HJ, Sperling M, et al. Rectal adenocarcinoma with choriocarcinomatous differentiation: clinical and genetic ascpects.















Hum Pathol. 2004;35(11):1427-30. []. [PMID:15668903]








Jeong JH, Cho YB, Park CM, et al. Adenocarcinoma of the rectum with choriocarcinomatous differentiation: a case report.















J Korean Soc Coloproctol. 2007;23(4):274-8. [].








Froylich D, Shiloni E, Lavie O, Neumann A, Vlodavsky E, Hazzan D. Colon and lung choriocarcinoma.















Isr Med Assoc J. 2010;12(10):642-4. [PMID:21090526]








Harada M, Inoue T, Hamano K. Choriocarcinoma of the sigmoid colon: a case report.















Surg Today. 2012;42(1):93-6. []. [PMID:22075658]








Maehira H, Shimizu T, Sonoda H, et al. A rare case of primary choriocarcinoma in the sigmoid colon.















World J Gastroenterol. 2013;19(39):6683-8. []. [PMID:24151399]








Mardi K, Gupta S, Gupta N, Mahajan V. Choriocarcinomatous differentiation in rectal adenocarcinoma: a rare occurrence.















South Asian J Cancer. 2014;3(2):144-5. []. [PMID:24818118]








Campo E, Palacin A, Benasco C, Quesada E, Cardesa A. Human chorionic gonadotrophin in colorectal carcinoma. An immunohistochemical study.















Cancer. 1987;59(9):1611-6. [<1611::AID-CNCR2820590915>3.0.CO;2-H]. [PMID:3548943]
























































































































































































































































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