Autopsy and Case Reports
Autopsy and Case Reports
Clinical Case Report

Rare occurrence of uterine arteriovenous malformation clinically mimicking a malignant growth: A critical reminder for pathologists

Trang K. Lollie; Steven S. Raman; Amir Qorbani; Ted Farzaneh; Neda A. Moatamed

Downloads: 1
Views: 1174


Arteriovenous malformation (AVM) is a rare lesion in the uterus, which can lead to abnormal uterine bleeding. While AVM has been described in other organs in the literature, there is a paucity of pathology reports of the AVM in uterus. On gross examination, the uterus was markedly enlarged and partly distorted with a pedunculated solid mass, which on the cut surface showed multiple well-circumscribed hemorrhagic cysts ranging from 0.1 to 4.0 cm in size. Microscopically, they were malformed dilated vascular structures containing organized thrombi. We present this case of uterine AVM with gross and microscopic findings, which can serve as a crucial reminder for pathologists to keep in the differential diagnoses as a potential cause of abnormal uterine bleeding.


Uterus, Arteriovenous Malformations, Pathology, Uterine Hemorrhage


Aslan H, Acar DK, Ekiz A, et al. Sonographic features and management options of uterine arteriovenous malformation: A case report.




Med Ultrason. 2015;17(4):561-3. []. [PMID:26649357]




Timmerman D, Van den Bosch T, Peeraer K, et al. Vascular malformations in the uterus: ultrasonographic diagnosis and conservative management.







Eur J Obstet Gynecol Reprod Biol. 2000;92(1):171-8. []. [PMID:10986453]




Sato E, Nakayama K, Nakamura K, Ishikawa M, Katagiri H, Kyo S. A case with life-threatening uterine bleeding due to postmenopausal uterine arteriovenous malformation.







BMC Womens Health. 2015;15(1):1-8. []. [PMID:25783637]




Yoon DJ, Jones M, Taani JA, Buhimschi C, Dowell JD. A systematic review of acquired uterine arteriovenous malformations: Pathophysiology, diagnosis, and transcatheter treatment.







AJP Rep. 2016;6(1):e6-14. []. [PMID:26929872]




Aiyappan SK, Ranga U, Veeraiyan S. Doppler sonography and 3D CT Angiography of Acquired Uterine Arteriovenous Malformations (AVMs): Report of two cases.







J Clin Diagn Res. 2014;8(2):187-9. []. [PMID:24701531]




Grivell RM, Reid KM, Mellor A. Uterine arteriovenous malformations: A review of the current literature.







Obstet Gynecol Surv. 2005;60(11):761-7. []. [PMID:16250925]




Hoffman MK, Meilstrup JW, Shackelford DP, Kaminski PF. Arteriovenous malformations of the uterus: an uncommon cause of vaginal bleeding.







Obstet Gynecol Surv. 1997;52(12):736-40. []. [PMID:9408929]




Przybojewski SJ, Sadler DJ. Novel image-guided management of a uterine arteriovenous malformation.







Cardiovasc Intervent Radiol. 2011;34(S2, Suppl 2):S161-6. []. [PMID:20694468]




Takeda A, Koyama K, Imoto S, Mori M, Sakai K, Nakamura H. Progressive formation of uterine arteriovenous fistula after laparoscopic-assisted myomectomy.







Arch Gynecol Obstet. 2009;280(4):663-7. []. [PMID:19224230]




Ishikawa T. Congenital arteriovenous malformations involving the pelvis and retroperitoneum: a case report.







Angiology. 1979;30(1):70-4. []. [PMID:426322]




Kasznica J, Nisar N. Congenital vascular malformation of the uterus in a stillborn: a case report.







Hum Pathol. 1995;26(2):240-1. []. [PMID:7860055]




Timmerman D, Wauters J, Van Calenbergh S, et al. Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations.







Ultrasound Obstet Gynecol. 2003;21(6):570-7. []. [PMID:12808674]




Szpera-Goździewicz A, Gruca-Stryjak K, Breborowicz GH, Ropacka-Lesiak M. Uterine arteriovenous malformation - diagnosis and management.







Ginekol Pol. 2018;89(5):276-9. []. [PMID:30084480]




Alessandrino F, Di Silverio E, Moramarco LP. Uterine arteriovenous malformation.







J Ultrasound. 2013;16(1):41-4. []. [PMID:24046800]




Vogelzang RL, Nemcek AA Jr, Skrtic Z, Gorrell J, Lurain JR. Uterine arteriovenous malformations: Primary treatment with therapeutic embolization.







J Vasc Interv Radiol. 1991;2(4):517-22. []. [PMID:1797218]




Hashim H, Nawawi O. Uterine arteriovenous malformation.







Malays J Med Sci. 2013;20(2):76-80. [PMID:23983582]




Katimada Annaiah T, Kodakkattil Sreenivasan S. Uterine arteriovenous malformations: Clinical implications.







Obstet Gynaecol. 2015;17(4):243-50. [].




Giuntoli RL 2nd, Metzinger DS, DiMarco CS, et al. Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy.







Gynecol Oncol. 2003;89(3):460-9. []. [PMID:12798712]




Fleming H, Ostor AG, Pickel H, Fortune DW. Arteriovenous malformations of the uterus.







Obstet Gynecol. 1989;73(2):209-14. [PMID:2643064]




Molvi SN, Dash K, Rastogi H, Khanna SB. Transcatheter embolization of uterine arteriovenous malformation: Report of 2 cases and review of literature.







J Minim Invasive Gynecol. 2011;18(6):812-9. []. [PMID:22024270]




Koyalakonda SP, Pyatt J. High output heart failure caused by a large pelvic arteriovenous malformation.







JRSM Short Rep. 2011;2(8):1-6. []. [PMID:21912732]
















































































































Publication date:

5eda921c0e88250a2a1dab05 autopsy Articles
Links & Downloads

Autops Case Rep

Share this page
Page Sections