Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.
Keywords
Breast, Schwann Cells, S100 Proteins
References
BeanSM, EloubeidiMA, EltoumIA, CerfolioRJ, JhalaDN, Preoperative diagnosis of a mediastinal granular cell tumour by EUS-FNA: a case report and review of the literature. Cytojournal. 2005;2(8):1-8.
DinizG, VuruskanerH, CelebilerH, OrtacR, AktasS, OzenerV. On üç yaşında bir kız çocukta, uyluk yumuşak dokusunda lokalize granüler hücreli tümör olgusu. Türkiye Ekopatoloji Dergisi. 2005;11(1):33-6.
NasierH, DanfortRDJr, SunbuliM, DimitrijevicO. Malignant granular cell tumour: case report with a novel karyotype and review of the literature. Ann Diagn Pathol. 2010;14(4):273-8. [https://doi.org/10.1016/j.anndiagpath.2009.08.004]. [PMID:20637434]
RexeenaB, PaulA, NitishRA, KurianC, AnilaRK. Granular cell tumour of breast: a case report and review of literature. Indian J Surg Oncol. 2015;6(4):446-8.
YangWT, Edeiken-MonroeB, SneigeN, FornageBD. Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound. 2006;34(4):153-60. [https://doi.org/10.1002/jcu.20227]. [PMID:16615051]
De SimoneN, AggonA, ChristyC. Granular cell tumor of the breast: clinical and pathologic characteristics of a rare case in a 14-year-old girl. J Clin Oncol. 2011;29(22):e656-7. [https://doi.org/10.1200/JCO.2011.35.9448]. [PMID:21646617]
HeinzerlingNP, KoehlerSM, SzaboS, WagnerAJ. Pediatric granular cell tumor of the breast: a case report and review of the literature. Case Rep Surg. 2015;2015:568940. [https://doi.org/10.1155/2015/568940]. [PMID:26491597]
BellezzaG, ColellaR, SidoniA, et al. Immunohistochemical expression og Galectin-3 and HMBE-1 in granular cell tumours: a new finding. Histol Histopathol. 2008;23(9):1127-30. [PMID:18581283]
Fanburg-SmithJC, Meis-KindblomJM, FanteR, KindblomLG. Malignant granular cell tumour of soft tissue; diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22(7):779-94. [https://doi.org/10.1097/00000478-199807000-00001]. [PMID:9669341]
Facebook
Google+
Twitter
LinkedIn
Mendeley
StumbleUpon
CiteULike
Reddit
Email