Small-cell ovarian carcinoma (SCOC) is a rare and aggressive neoplasia, predominantly affecting young women who are frequently first diagnosed with advanced stage disease. Platinum-based chemotherapy (ChT) can provide high response rates and rapidly ameliorate symptoms in this scenario. However, progression after chemotherapy usually occurs quickly, leading to high mortality rates. In addition, ChT complications, such as tumor lysis syndrome (TLS) can also occur, jeopardizing the patient’s outcome. We present a case of metastatic SCOC in a 47-year-old patient who achieved tumor response after platinum-based chemotherapy and developed TLS, from which she recovered with supportive treatment. After the second ChT cycle, she developed febrile neutropenia and died 8 weeks after the diagnosis of SCOC. Although SCOC is a chemo-sensitive tumor, short-lived responses and frequent chemotherapy complications lead to a dismal prognosis.
Keywords
Ovarian Neoplasms, Carcinoma, Small Cell, Tumor Lysis Syndrome, Drug Therapy
LevitanN, DowlatiA, RemickSC, et al.Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine (Baltimore). 1999;78(5):285-91. http://dx.doi.org/ [https://doi.org/10.1097/00005792-199909000-00001]. PMid: [PMID:10499070]
FukuokaM, FuruseK, SaijoN, et al.Randomized trial of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small-cell lung cancer. J Natl Cancer Inst. 1991;83(12):855-61. http://dx.doi.org/ [https://doi.org/10.1093/jnci/83.12.855]. PMid: [PMID:1648142]
SundstrømS, BremnesRM, KaasaS, et al, and the Norwegian Lung Cancer Study Group. Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years’ follow-up. J Clin Oncol. 2002;20(24):4665-72. http://dx.doi.org/ [https://doi.org/10.1200/JCO.2002.12.111]. PMid: [PMID:12488411]
DykgraafRH, de JongD, van VeenM, Ewing-GrahamPC, HelmerhorstTJ, van der BurgME. Clinical management of ovarian small-cell carcinoma of the hypercalcemic type: a proposal for conservative surgery in an advanced stage of disease. Int J Gynecol Cancer. 2009;19(3):348-53. http://dx.doi.org/ [https://doi.org/10.1111/IGC.0b013e3181a1a116]. PMid: [PMID:19407558]
RovithiM, PallisAG, KalykakiA, et al. Small cell ovarian cancer in adolescents: report of two cases and review of the literature. Case Rep Med. 2011;2011:1-4. http://dx.doi.org/ [https://doi.org/10.1155/2011/749516]. PMid:21738537
PautierP, RibragV, DuvillardP, et al.Results of a prospective dose-intensive regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type. Ann Oncol. 2007;18(12):1985-9. http://dx.doi.org/ [https://doi.org/10.1093/annonc/mdm376]. PMid: [PMID:17761699]
Facebook
Google+
Twitter
LinkedIn
Mendeley
StumbleUpon
CiteULike
Reddit
Email