Although neonatal tumors are rare, neuroblastoma is the most common neoplasia among them. These tumors, which usually involve children in early infancy, are derived from neural crest cells of adrenal gland medulla or sympathetic ganglia. Even though congenital metastatic neuroblastoma presents a favorable prognosis, it may lead to death if not recognized and treated early on. The authors report the case of a 2-month-old child who was born from in vitro fertilization, and whose diagnosis was made after birth. The form of presentation of this case as a metastatic disease concerning this age group is noteworthy.
Brodeur GM, Maris JM. Neuroblastoma. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 5th ed. Philadelphia: J B Lippincott Company; 2006. p. 933-70.
ShimadaH, ChattenJ, NewtonWAJr, et al.Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst. 1984;73(2):405-16. PMid: [PMID:6589432].
PeuchmaurM, d’AmoreES, JoshiVV, et al.Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003;98(10):2274-81. http://dx.doi.org/ [https://doi.org/10.1002/cncr.11773]. PMid: [PMID:14601099]
BrodeurGM, PritchardJ, BertholdF, et al.Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11(8):1466-77. PMid: [PMID:8336186].
TaggartDR, LondonWB, SchmidtML, et al.Prognostic value of the stage 4S metastatic pattern and tumor biology in patients with metastatic neuroblastoma diagnosed between birth and 18 months of age. J Clin Oncol. 2011;29(33):4358-64. http://dx.doi.org/ [https://doi.org/10.1200/JCO.2011.35.9570]. PMid: [PMID:21969516]
SchleiermacherG, RubieH, HartmannO, et al, and the Neuroblastoma Study Group of the French Society of Paediatric Oncology. Treatment of stage 4s neuroblastoma—report of 10 years’ experience of the French Society of Paediatric Oncology (SFOP). Br J Cancer. 2003;89(3):470-6. http://dx.doi.org/ [https://doi.org/10.1038/sj.bjc.6601154]. PMid: [PMID:12888814]
TurkelSB, ItabashiHH. The natural history of neuroblastic cells in the fetal adrenal gland. Am J Pathol. 1974;76(2):225-44. PMid: [PMID:4843383].
BolandeRP. The spontaneous regression of neuroblastoma. Experimental evidence for a natural host immunity. Pathol Annu. 1991;26(Pt 2):187-99. PMid: [PMID:1861885].
BulunA, SariciSU, SoyerOU, TekşamO, YurdakökM, CağlarM. The triad of nesidioblastosis, congenital neuroblastoma and glomerulocystic disease of the newborn: a case report. Turk J Pediatr. 2005;47(3):298-302. PMid: [PMID:16250322].