Although the Pseudomonas aeruginosa infection is well known and frequently found in hospitals and nursing care facilities, many cases are also reported outside these boundaries. In general, this pathogen infects debilitated patients either by comorbidities or by any form of immunodeficiency. In cases of respiratory infection, tobacco abuse seems to play an important role as a risk factor. In previously healthy patients, community-acquired pneumonia (CAP) with P. aeruginosa as the etiological agent is extremely rare, and unlike the cases involving immunocompromised or hospitalized patients, the outcome is severe, and is fatal in up to 61.1% of cases. Aerosolized contaminated water or solutions are closely linked to the development of respiratory tract infection. In this setting, metalworking fluids used in factories may be implicated in CAP involving previously healthy people. The authors report the case of a middle-aged man who worked in a metalworking factory and presented a right upper lobar pneumonia with a rapid fatal outcome. P. aeruginosa was cultured from blood and tracheal aspirates. The autopsy findings confirmed a hemorrhagic necrotizing pneumonia with bacteria-invading vasculitis and thrombosis. A culture of the metalworking fluid of the factory was also positive for P. aeruginosa. The pulsed-field gel electrophoresis showed that both strains (blood culture and metalworking fluid) were genetically indistinguishable. The authors highlight the occupational risk for the development of this P.aeruginosa-infection in healthy people.
RibotEM, FairMA, GautomR, et al.Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis. 2006;3(1):59-67. http://dx.doi.org/ [https://doi.org/10.1089/fpd.2006.3.59]. PMid: [PMID:16602980]
TenoverFC, ArbeitRD, GoeringRV, et al.Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233-9. PMid: [PMID:7494007].
HatchetteTF, GuptaR, MarrieTJ. Pseudomonas aeruginosa community-acquired pneumonia in previously healthy adults: case report and review of the literature. Clin Infect Dis. 2000;31(6):1349-56. http://dx.doi.org/ [https://doi.org/10.1086/317486]. PMid: [PMID:11096001]
TakajoD, IwayaK, KatsuradaY, et al.Community-acquired lobar pneumonia caused by Pseudomonas aeruginosa infection in Japan: a case report with histological and immunohistochemical examination. Pathol Int. 2014;64(5):224-30. http://dx.doi.org/ [https://doi.org/10.1111/pin.12162]. PMid: [PMID:24888776]
Gerald BP, Ramphal R. Pseudomonas aeruginosa. In: Mandell GL, Bennet JE, Dolin R, editors. Principles and practice of infectious diseases. 7th ed. Philadelphia: Churchill Livingstone, Elsevier; 2010. p. 2835-60.
MatarGM, HarakehHS, RamlawiF, KhneisserI, HadiU. Comparative analysis between Pseudomonas aeruginosa genotypes and severity of symptoms in patients with unilateral or bilateral otitis externa. Curr Microbiol. 2001;42(3):190-3. http://dx.doi.org/ [https://doi.org/10.1007/s002840010202]. PMid: [PMID:11270653]
Centers for Disease Control and Prevention (CDC). Pseudomonas dermatitis/folliculitis associated with pools and hot tubs—Colorado and Maine, 1999-2000. MMWR Morb Mortal Wkly Rep. 2000;49(48):1087-91. PMid: [PMID:11130858].
von BaumH, WelteT, MarreR, SuttorpN, EwigS.CAPNETZ Study Group. Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: Diagnosis, incidence and predictors. Eur Respir J. 2010;35(3):598-605. http://dx.doi.org/ [https://doi.org/10.1183/09031936.00091809]. PMid: [PMID:19679601]
KaplanV, AngusDC, GriffinMF, ClermontG, Scott WatsonR, Linde-ZwirbleWT. Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med. 2002;165(6):766-72. http://dx.doi.org/ [https://doi.org/10.1164/ajrccm.165.6.2103038]. PMid: [PMID:11897642]
HarrisAA, GoodmanL, LevinS. Community-acquired Pseudomonas aeruginosa pneumonia associated with the use of a home humidifier. West J Med. 1984;141(4):521-3. PMid: [PMID:6506689].
HoogwerfBJ, KhanMY. Community-acquired bacteremic Pseudomonas pneumonia in a health adult. Am Rev Respir Dis. 1981;123(1):132-4. PMid: [PMID:6779684].
JayatillekeK, BandaraP, SatharasingheR.A case of community acquired pneumonia caused by Pseudomonas aeruginosa. Sri Lanka J Infect Dis. 2012;2:53-4.
TantCO, BennettEO. The growth of aerobic bacteria in metal-cutting fluids. Appl Microbiol. 1958;6(6):388-91. PMid: [PMID:13595648].
ZellL, MackU, SommerfeldA, BuchterA, SybrechtGW. Abszedierende Pneumonie durch Pseudomonas aeruginosa als Berufskrankheit bei einem Bohrwerksdreher. Pneumologie. 1999;53(12):620-5. http://dx.doi.org/ [https://doi.org/10.1055/s-1999-9052].
JaksićS, UhitilS, ZivkovićJ. Bacterial pollution of cutting fluids: a risk factor for occupational diseases. Arh Hig Rada Toksikol. 1998;49(3):239-44. PMid: [PMID:10376355].
ChazalPM. Pollution of modern metalworking fluids containing biocides by pathogenic bacteria in France. Reexamination of chemical treatments accuracy. Eur J Epidemiol. 1995;11(1):1-7. http://dx.doi.org/ [https://doi.org/10.1007/BF01719939]. PMid: [PMID:7489767]
HarrodKS, JaramilloRJ, BergerJA, GigliottiAP, SeilkopSK, ReedMD. Inhaled diesel engine emissions reduce bacterial clearance and exacerbate lung disease to Pseudomonas aeruginosa infection in vivo. Toxicol Sci. 2005;83(1):155-65. http://dx.doi.org/ [https://doi.org/10.1093/toxsci/kfi007]. PMid: [PMID:15483187]
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